Temporal dynamics of a T-cell mediated immune response in desert rodents
Temporal dynamics of a T-cell mediated immune response in desert rodents
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DOI：
10.1016/j.cbpa.2006.08.045
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发表时间：
2006-12-01
影响因子：
2.3
通讯作者：
Pinshow, Berry
中科院分区：
文献类型：
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作者：
de Bellocq, Joelle Gouy;Krasnov, Boris R.;Pinshow, Berry
免疫能力是指个体宿主对病原体发起免疫反应的一般能力，通常通过注射植物血凝素(PHA)来评估免疫系统对挑战的反应。对PFA的反应通常被认为是T细胞介导的免疫反应的可靠估计。我们研究了来自以色列内盖夫沙漠的10种啮齿动物的PHA反应的时间模式。我们假设，PHA反应的时间动态在具有不同自然跳蚤寄生模式的物种之间会有所不同。每只大鼠足底皮下注射PHA，分别于注射后6、24、48h测定其PHA反应。啮齿动物表现出两种类型的PHA反应。一种是快速且具有特征的啮齿动物，这种啮齿动物要么有物种稀少的跳蚤集合，要么很少受到跳蚤的攻击。这种反应在注射PHA后6h达到高峰。第二种类型的反应是延迟的，这是典型的啮齿类动物，要么有物种丰富的跳蚤集合，要么有高度丰富和流行的跳蚤，或者两者兼而有之。它们对PHA的反应在注射后24小时达到高峰。此外，反应迅速的啮齿动物比反应迟缓的啮齿动物的最大反应要低。我们的结果表明，PHA反应的强度和潜伏期之间存在权衡，因此，在进行免疫活性的种间比较时，有必要考虑最大PHA反应与注射后时间之间的关系。(C)2006 Elsevier Inc.保留所有权利。
Immunocompetence, the general capacity of an individual host to mount an immune response against pathogens, is commonly assessed by the response to a challenge of the immune system by injection of phytohaemagglutinin (PHA). The response to PFA is commonly considered a reliable estimate of the T-cell mediated immune response. We investigated the temporal pattern of the PHA response in 10 rodent species from the Negev desert, Israel. We hypothesized that the temporal dynamics of the PHA response would differ among species with different natural patterns of flea parasitism. We injected PHA subcutaneously in the footpad of each rodent and measured its PHA response 6, 24 and 48 h after injection. Rodent species showed two types of PHA response. One type was rapid and characteristic of rodents that had either species-poor flea assemblages, or that are rarely attacked by fleas. This response peaked similar to 6 h after PHA injection. The second type of response was delayed and was typical of rodents that have either species-rich flea assemblages or high abundance and prevalence of fleas or both. Their response to PHA peaked 24 h after injection. Furthermore, rodents that responded promptly had a lower maximum response than rodents with a delayed response. Our results suggest the occurrence of a trade-off between intensity and latency of the PHA response and, therefore, the necessity to account for the relationship between maximum PHA response and time after injection when making interspecific comparisons of immunocompetence. (c) 2006 Elsevier Inc. All rights reserved.