Circadian Deregulation as Possible New Player in Pollution-Induced Tissue Damage
Circadian Deregulation as Possible New Player in Pollution-Induced Tissue Damage
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DOI：
10.3390/atmos12010116
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发表时间：
2021-01-01
期刊：
影响因子：
2.9
通讯作者：
Valacchi, Giuseppe
中科院分区：
文献类型：
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作者：
Benedusi, Mascia;Frigato, Elena;Valacchi, Giuseppe
昼夜节律是由下丘脑主振荡器驱动的24小时振荡，它携带着几乎所有细胞、组织和器官的外周时钟。由工业化和现代生活方式引发的昼夜节律失调与几种病理情况有关，可能会损害生命的质量，甚至是生命的存在。生物体不断暴露在空气污染物中，其中臭氧或颗粒物(PM)被认为是对人类健康危害最大的污染物之一。特别是，暴露在环境应激源下不仅可能导致肺病和心血管疾病，而且，正如过去20年所证明的那样，皮肤也可能受到污染的影响。在这种情况下，我们假设时间紊乱可以加剧细胞对外源性损害剂的脆弱性，我们建议了一种可能的共同作用机制，即解除肺、心血管和皮肤组织的内稳态调节，并参与其参与病理条件的发展。
Circadian rhythms are 24-h oscillations driven by a hypothalamic master oscillator that entrains peripheral clocks in almost all cells, tissues and organs. Circadian misalignment, triggered by industrialization and modern lifestyles, has been linked to several pathological conditions, with possible impairment of the quality or even the very existence of life. Living organisms are continuously exposed to air pollutants, and among them, ozone or particulate matters (PMs) are considered to be among the most toxic to human health. In particular, exposure to environmental stressors may result not only in pulmonary and cardiovascular diseases, but, as it has been demonstrated in the last two decades, the skin can also be affected by pollution. In this context, we hypothesize that chronodistruption can exacerbate cell vulnerability to exogenous damaging agents, and we suggest a possible common mechanism of action in deregulation of the homeostasis of the pulmonary, cardiovascular and cutaneous tissues and in its involvement in the development of pathological conditions.