A calibration-free, one-step method for quantitative photoacoustic tomography.
A calibration-free, one-step method for quantitative photoacoustic tomography.
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DOI：
10.1118/1.4760981
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发表时间：
2012-11
期刊：
影响因子：
3.8
通讯作者：
Zhen Yuan;Huabei Jiang
中科院分区：
文献类型：
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作者：
Zhen Yuan;Huabei Jiang
目的最近报道的定量光声断层扫描（PAT）显着扩展了 PAT 的用途，因为它可以恢复与组织生理信息直接相关的组织光吸收系数。然而，现有定量PAT方法对光吸收系数的恢复很大程度上取决于吸收能量密度分布的准确性，以及对入射光源的准确强度和分布的了解。本研究的目的是开发一种不依赖于这些初始参数的光吸收系数重建新算法。方法在这里，作者提出了一种新颖的一步重建方法，可以直接从沿边界域的光声测量中恢复光吸收系数。作者使用模拟和模型实验验证了该方法。结果作者证明了实验证据表明，只需一步使用边界光声测量与光子扩散方程即可直接恢复光吸收系数图。作者发现，所描述的方法能够定量重建具有不同尺寸和光学对比度水平的吸收物体。结论与作者之前的两步方法相比，这里获得的重建结果表明一步方案可以显着提高吸收系数恢复的准确性。
PURPOSE Recently reported quantitative photoacoustic tomography (PAT) has significantly expanded the utilities of PAT because it allows for recovery of tissue optical absorption coefficient which directly correlates with tissue physiological information. However, the recovery of optical absorption coefficient by the existing quantitative PAT approaches strongly depends on the accuracy of absorbed energy density distribution, and on the knowledge of accurate strength and distribution of incident light source. The purpose of this study is to develop a new algorithm for the reconstruction of optical absorption coefficient that does not depend on these initial parameters. METHODS Here the authors propose a novel one-step reconstruction approach that can directly recover optical absorption coefficient from photoacoustic measurements along boundary domain. The authors validate the method using simulation and phantom experiments. RESULTS The authors have demonstrated experimental evidence that it is possible to directly recover optical absorption coefficient maps using boundary photoacoustic measurements coupled with the photon diffusion equation in just one step. The authors found that the method described is able to quantitatively reconstruct absorbing objects with different sizes and optical contrast levels. CONCLUSIONS Compared to the authors' previous two-step methods, the reconstruction results obtained here show that the one-step scheme can significantly improve the accuracy of absorption coefficient recovery.