OVARIECTOMY, SOCIAL-STATUS, AND ATHEROSCLEROSIS IN CYNOMOLGUS MONKEYS
OVARIECTOMY, SOCIAL-STATUS, AND ATHEROSCLEROSIS IN CYNOMOLGUS MONKEYS
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DOI：
10.1161/01.atv.5.2.192
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
KORITNIK, DR
中科院分区：
文献类型：
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作者：
ADAMS, MR;KAPLAN, JR;KORITNIK, DR
关于自然绝经或手术绝经对女性预防冠状动脉粥样硬化的影响，证据是相互矛盾的。在21只切除卵巢和23只完整雌性食蟹猴中评价动脉粥样硬化、血脂、血压和碳水化合物耐受性，这些食蟹猴喂食中度致动脉粥样硬化饮食30个月。社会优势地位的影响，特别强调与卵巢内分泌功能的可能关系进行了评估。卵巢切除雌性动物的冠状动脉、颈动脉和髂股动脉的动脉粥样硬化程度为2-10倍;这可以部分解释为总血浆和LDL [低密度脂蛋白]胆固醇浓度增加15-20%。社会主导的完整的女性对冠状动脉的高级动脉粥样硬化病变（斑块）的保护，而下属的女性和卵巢切除的女性没有。在从属完整的女性中，对晚期冠状动脉粥样硬化的易感性增加可能在某种程度上与在这些个体中的7/12中观察到的慢性卵巢功能障碍有关。作为一个小组下属完整的女性也有扩大的肾上腺，提示机制，可能会影响动脉粥样硬化的独立。在这个物种中，卵巢切除术和慢性卵巢功能障碍与从属的社会地位与更动脉粥样硬化的血脂模式，并取消女性对冠状动脉粥样硬化的保护。
Evidence is contradictory regarding the effects of natural or surgical menopause on female protection against coronary artery atherosclerosis. Atherosclerosis, plasma lipids, blood pressure and carbohydrate tolerance was evaluated in 21 ovariectomized and 23 intact female cynomolgus macaques fed a moderately atherogenic diet for 30 mo. The influence of social dominance status, was evaluated with particular emphasis on a possible relation with ovarian endocrine function. Atherosclerosis was 2-10 times as extensive in coronary, carotid and iliaco-femoral arteries of the ovariectomized females; this could be explained, in part, by 15-20% increases in total plasma and LDL [low-density lipoprotein] cholesterol concentrations. Socially dominant intact females were protected against advanced atherosclerotic lesions (plaques) of the coronary arteries, while subordinate females and ovariectomized females were not. Increased susceptibility to advanced coronary artery atherosclerosis in subordinate intact females may have been related in some way to chronic ovarian dysfunction observed in 7 of 12 of these individuals. As a group subordinate intact females also had enlarged adrenal glands, suggestive of mechanisms that may influence atherogenesis independently. In this species, ovariectomy and chronic ovarian dysfunction related to subordinate social status are associated with a more atherogenic plasma lipid pattern and abolish female protection against coronary artery atherosclerosis.