Coffee Consumption Habits and the Risk of Mild Cognitive Impairment: The Italian Longitudinal Study on Aging
Coffee Consumption Habits and the Risk of Mild Cognitive Impairment: The Italian Longitudinal Study on Aging
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DOI：
10.3233/jad-150333
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发表时间：
2015-01-01
影响因子：
4
通讯作者：
Scafato, Emanuele
中科院分区：
文献类型：
--
作者：
Solfrizzi, Vincenzo;Panza, Francesco;Scafato, Emanuele
咖啡、茶或咖啡因的摄入可能对认知障碍和痴呆症有保护作用。我们估计了咖啡消费习惯的改变或不变与轻度认知障碍（MCI）发生率之间的关系。我们评估了从意大利老龄化纵向研究中招募的5，632名年龄在65-84岁之间的受试者中的1，445名受试者，该研究是一项基于人口的样本，来自8个意大利城市，中位随访时间为3.5年。认知正常的老年人，习惯性饮用适量咖啡（1 - 2杯咖啡/天）的MCI发病率低于从不或很少喝咖啡的人[1杯/天：风险比（HR）：0.47，95%置信区间（CI）：0.211 - 1.02或1-2杯/天：HR：0.31 95% CI：0.13至0.75]。对于认知正常的老年受试者谁改变了他们的咖啡消费习惯，那些增加咖啡消费量，与那些有固定习惯的人相比，每天喝咖啡超过1杯的人MCI的发病率更高（最多+/- 1杯咖啡/天）（HR：1.80，95% CI：1.11 - 2.92）或减少消费者（2杯咖啡/天）和MCI的发病率与从不或很少喝咖啡的人相比（HR：0.26，95% CI：0.03 - 2.11）。总之，认知正常的老年人谁增加了他们的咖啡消费有较高的发展MCI的比率，而恒定的时间适度的咖啡消费与MCI的发病率降低。
Coffee, tea, or caffeine consumption may be protective against cognitive impairment and dementia. We estimated the association between change or constant habits in coffee consumption and the incidence of mild cognitive impairment (MCI). We evaluated 1,445 individuals recruited from 5,632 subjects, aged 65-84 year old, from the Italian Longitudinal Study on Aging, a population-based sample from eight Italian municipalities with a 3.5-year median follow-up. Cognitively normal older individuals who habitually consumed moderate amount of coffee (from 1 to 2 cups of coffee/day) had a lower rate of the incidence of MCI than those who never or rarely consumed coffee [1 cup/day: hazard ratio (HR): 0.47, 95% confidence interval (CI): 0.211 to 1.02 or 1-2 cups/day: HR: 0.31 95% CI: 0.13 to 0.75]. For cognitively normal older subjects who changed their coffee consumption habits, those increasing coffee consumption (>1 cup of coffee/day) had higher rate of the incidence of MCI compared to those with constant habits (up to +/- 1 cup of coffee/day) (HR: 1.80, 95% CI: 1.11 to 2.92) or those with reduced consumption (2 cups of coffee/day) and the incidence of MCI in comparison with those who never or rarely consumed coffee (HR: 0.26, 95% CI: 0.03 to 2.11). In conclusion, cognitively normal older individuals who increased their coffee consumption had a higher rate of developing MCI, while a constant in time moderate coffee consumption was associated to a reduced rate of the incidence of MCI.