The Emerging Role of Polo-Like Kinase 1 in Epithelial-Mesenchymal Transition and Tumor Metastasis.
The Emerging Role of Polo-Like Kinase 1 in Epithelial-Mesenchymal Transition and Tumor Metastasis.
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DOI：
10.3390/cancers9100131
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发表时间：
2017-09-27
期刊：
影响因子：
5.2
通讯作者：
Wen D
中科院分区：
文献类型：
--
作者：
Fu Z;Wen D
Polo样激酶1（PLK 1）是一种丝氨酸/苏氨酸激酶，在细胞周期调控中起关键作用。PLK 1在多种人类肿瘤中过表达，其表达水平通常与癌症患者中细胞增殖增加和预后不良相关。已经表明PLK 1通过多种机制控制癌症发展，包括有丝分裂和胞质分裂的规范调节、DNA复制的调节和细胞存活。然而，新出现的证据表明PLK 1在肿瘤发展过程中的新的和以前未预料到的作用。本文就PLK 1在上皮-间质转化和肿瘤侵袭中的作用作一综述。我们将进一步讨论这些功能的治疗潜力。
Polo-like kinase 1 (PLK1) is a serine/threonine kinase that plays a key role in the regulation of the cell cycle. PLK1 is overexpressed in a variety of human tumors, and its expression level often correlates with increased cellular proliferation and poor prognosis in cancer patients. It has been suggested that PLK1 controls cancer development through multiple mechanisms that include canonical regulation of mitosis and cytokinesis, modulation of DNA replication, and cell survival. However, emerging evidence suggests novel and previously unanticipated roles for PLK1 during tumor development. In this review, we will summarize the recent advancements in our understanding of the oncogenic functions of PLK1, with a focus on its role in epithelial-mesenchymal transition and tumor invasion. We will further discuss the therapeutic potential of these functions.
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