Self-assembly of synthetic hydroxyapatite nanorods into an enamel prism-like structure
Self-assembly of synthetic hydroxyapatite nanorods into an enamel prism-like structure
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DOI：
10.1016/j.jcis.2005.02.064
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发表时间：
2005-08-01
影响因子：
9.9
通讯作者：
Mansfield, JF
中科院分区：
文献类型：
--
作者：
Chen, HF;Clarkson, BH;Mansfield, JF
应用表面活性剂作为反胶束或微乳液来合成和自组装纳米级结构是纳米技术中最广泛采用的方法之一。这些合成的纳米结构组件有时具有有序排列。这项研究的目的是利用纳米技术领域的最新发展来模拟自然生物矿化过程，以创造人体中最坚硬的组织——牙釉质。这是牙齿的最外层，由牙釉质棱柱组成，牙釉质棱柱是高度组织的纳米棒状羟基磷灰石钙 (HA) 晶体的微观结构单元，彼此大致平行排列。特别是，我们用单层表面活性剂合成并修饰了羟基磷灰石纳米棒表面，以产生特定的表面特性，使纳米棒在水/空气界面处自组装成牙釉质棱柱状结构。合成羟基磷灰石纳米棒的尺寸是可以控制的，我们合成了与人类和大鼠牙釉质尺寸相似的纳米棒。使用透射电子显微镜（TEM）和原子力显微镜（AFM）检查制备的纳米棒组件。特定的 Langmuir-Blodgett 薄膜由釉质棱柱状纳米棒组件组成，Ca/P 比在 1.6 至 1.7 之间。 (c) 2005 Elsevier Inc. 保留所有权利。
The application of surfactants as reverse micelles or microemulsions for the synthesis and self-assembly of nanoscale structures is one of the most widely adopted methods in nanotechnology. These synthesized nanostructure assemblies sometimes have an ordered arrangement. The aim of this research was to take advantage of these latest developments in the area of nanotechnology to mimic the natural biomineralization process to create the hardest tissue in the human body, dental enamel. This is the outermost layer of the teeth and consists of enamel prisms, highly organized micro-architectural units of nanorod-like Calcium hydroxyapatite (HA) crystals arranged roughly parallel to each other. In particular, we have synthesized and modified the hydroxyapatite nanorods Surface with monolayers of surfactants to create specific surface characteristics which will allow the nanorods to self-assemble into an enamel prism-like structure at a water/air interface. The size of the synthetic hydroxyapatite nanorods can be controlled and we have synthesized nanorods similar in size to both human and rat enamel. The prepared nanorod assemblies were examined using transmission electron microscopy (TEM) and atomic force microscopy (AFM). The specific Langmuir-Blodgett films were shown to be comprised of enamel prism-like nanorod assemblies with a Ca/P ratio between 1.6 and 1.7. (c) 2005 Elsevier Inc. All rights reserved.