Boosting Room Temperature Phosphorescence Performance by Alkyl Modification for Intravital Orthotopic Lung Tumor Imaging
Boosting Room Temperature Phosphorescence Performance by Alkyl Modification for Intravital Orthotopic Lung Tumor Imaging
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DOI：
10.1002/smll.202005449
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发表时间：
2021-02-18
期刊：
影响因子：
13.3
通讯作者：
Ding, Dan
中科院分区：
文献类型：
--
作者：
Gao, Heqi;Gao, Zhiyuan;Ding, Dan
纯有机室温磷光材料由于其在生物成像等方面的巨大应用潜力而受到广泛关注。然而，由于对三重态激子的高要求，制备具有相当高效率和长寿命的有机RTP材料仍然是一个挑战。在这项研究中，一系列的酮衍生物与有效的RTP在晶体中开发通过简单的烷基基团的分子聚集状态的调节，从而产生令人印象深刻的发光性能与更长的寿命和更高的效率，分别高达868 ms和51.59%，分别。所有的烷基取代的衍生物表现出明亮的RTP强度后，用杵重研磨，表明其强大的RTP功能，这是适用于许多领域。鼓励这些发光体在结晶状态下的优异RTP性能，成功的原位肺肿瘤成像与高信号-背景比（SBR）的65，在这项研究中被证明，提供用于疾病诊断的纯有机RTP材料的承诺，它具有低自发荧光干扰和高信号-背景比的优点。
Pure organic persistent room temperature phosphorescence (RTP) materials have attracted wide attention owing to their great potential in various applications, particularly in bioimaging. However, it is still a challenge to manufacture organic RTP materials possessing quite high efficiency and long lifetime, owing to the high requirements for triplet excitons. In this study, a series of keto derivatives with efficient RTP in crystals are developed through the regulation of molecular aggregation states by simple alkyl groups, resulting in impressive luminescence performance with a longer lifetime and higher efficiency of up to 868 ms and 51.59%, respectively. All the alkyl-substituted derivatives exhibit bright RTP intensities after heavy grinding with a pestle, indicating their robust RTP features, which are suitable for many fields. Encouraged by the excellent RTP performance of these luminogens in the crystalline state, successful orthotopic lung tumor imaging with a high signal-to-background ratio (SBR) of 65 is demonstrated in this study to provide the promise of pure organic RTP materials for disease diagnosis, which hold the advantages of low autofluorescence interference and high signal-to-background ratio.