MicroRNAs Regulate Key Effector Pathways of Senescence.
MicroRNAs Regulate Key Effector Pathways of Senescence.
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DOI：
10.4061/2011/205378
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发表时间：
2011
影响因子：
4.7
通讯作者：
Lleonart ME
中科院分区：
文献类型：
--
作者：
Feliciano A;Sánchez-Sendra B;Kondoh H;Lleonart ME
microRNAs（miRNAs）是一类长度约为22 nt的内源性非编码RNA分子，通过与靶基因3′端非翻译区（UTR）碱基配对来调控基因表达和蛋白质编码。miRNA表达与癌症发病机制相关，因为miRNA与癌症发展密切相关。衰老阻断细胞增殖，代表细胞必须绕过以达到恶性的重要屏障。重要的是，某些miRNA已被证明在细胞衰老过程中发挥重要作用，这也参与了人类肿瘤的发生。因此，通过药物或基于miRNA的疗法治疗性诱导衰老是通过诱导肿瘤中的持续生长停滞来治疗癌症的潜在方法。
MicroRNAs (miRNAs) are small (approximately 22 nt) noncoding endogenous RNA molecules that regulate gene expression and protein coding by base pairing with the 3′ untranslated region (UTR) of target mRNAs. miRNA expression is associated with cancer pathogenesis because miRNAs are intimately linked to cancer development. Senescence blocks cell proliferation, representing an important barrier that cells must bypass to reach malignancy. Importantly, certain miRNAs have been shown to have an important role during cellular senescence, which is also involved in human tumorigenesis. Therefore, therapeutic induction of senescence by drugs or miRNA-based therapies is a potential method to treat cancer by inducing a persistent growth arrest in tumors.