Revisiting Current Concepts on the Tolerogenicity of Steady-State Dendritic Cell Subsets and Their Maturation Stages
Revisiting Current Concepts on the Tolerogenicity of Steady-State Dendritic Cell Subsets and Their Maturation Stages
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DOI：
10.4049/jimmunol.2001315
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发表时间：
2021-04
期刊：
影响因子：
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通讯作者：
M. Lutz;R. Backer;B. Clausen
中科院分区：
文献类型：
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作者：
M. Lutz;R. Backer;B. Clausen
最初的概念认为，未成熟的树突状细胞（DC）具有耐受性，而成熟的DC具有严格的免疫原性。同时，所有常规DC亚群的表型成熟阶段都可以通过将自身抗原转运到淋巴结，对调节性T细胞发挥独特的功能，从而促进稳态迁移DC的耐受性。我们提出，在体内，1)在CD4 T细胞能量诱导等稳定状态下，未成熟DC具有耐受功能的证据很少；2)作为稳态迁移DC的所有耐受都经历了共同的以及亚群特异性的分子变化；3)这些变化在定量和定性标记上与免疫原性DC不同，这使得人们可以清楚地区分耐受性DC和免疫原性迁移DC。
The original concept stated that immature dendritic cells (DC) act tolerogenically whereas mature DC behave strictly immunogenically. Meanwhile, it is also accepted that phenotypically mature stages of all conventional DC subsets can promote tolerance as steady-state migratory DC by transporting self-antigens to lymph nodes to exert unique functions on regulatory T cells. We propose that in vivo 1) there is little evidence for a tolerogenic function of immature DC during steady state such as CD4 T cell anergy induction, 2) all tolerance as steady-state migratory DC undergo common as well as subset-specific molecular changes, and 3) these changes differ by quantitative and qualitative markers from immunogenic DC, which allows one to clearly distinguish tolerogenic from immunogenic migratory DC.