Digitalis; impinges on more than just the (ion-) pump
Digitalis; impinges on more than just the (ion-) pump
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DOI：
10.1016/s0306-9877(02)00334-1
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发表时间：
2002-12-01
影响因子：
4.7
通讯作者：
Haux, J
中科院分区：
文献类型：
--
作者：
Haux, J
Some forms of digitalis, such as digitoxin, inhibits proliferation and induces apoptosis in cancer cells in clinically relevant concentrations. Recently, it has been demonstrated that digitalis, in addition to inhibiting the Na+/K+-ATPase, also signals through the pathways of the epidermal growth factor receptor (EGFR). Digitalis has complex dose-dependent mechanisms of action involving many signaling systems and the relevance of this for the anticancer effects are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.
