Circadian rhythms, nutrition and implications for longevity in urban environments
Circadian rhythms, nutrition and implications for longevity in urban environments
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DOI：
10.1017/s0029665117003962
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发表时间：
2018-08-01
影响因子：
7
通讯作者：
Froy, O.
中科院分区：
文献类型：
--
作者：
Froy, O.
目前，约12%的人口为65岁或以上，到2030年，这一数字预计将达到21%。为了促进老年人的福祉和减少与保健需求有关的费用，在延长寿命的同时应减少衰老。能量限制，将消耗的能量限制在每日摄入量的60-70%，间歇性禁食，允许每隔一天随意进食，延长哺乳动物的寿命，预防或延迟与年龄有关的主要疾病，如癌症，糖尿病和白内障的发病。最近，我们已经表明，幸福可以通过重置生物钟和诱导强大的分解代谢昼夜节律通过定时喂养。此外，生物钟机制调节代谢，主要代谢蛋白是核心生物钟机制的关键因素。因此，有必要增加我们对代谢和寿命的昼夜节律调节的理解，并根据这种调节设计新的治疗方法。本文将探讨目前的数据在该领域的昼夜节律，衰老和代谢。
Presently, about 12% of the population is 65 years or older and by the year 2030 that figure is expected to reach 21%. In order to promote the well-being of the elderly and to reduce the costs associated with health care demands, increased longevity should be accompanied by ageing attenuation. Energy restriction, which limits the amount of energy consumed to 60-70% of the daily intake, and intermittent fasting, which allows the food to be available ad libitum every other day, extend the life span of mammals and prevent or delay the onset of major age-related diseases, such as cancer, diabetes and cataracts. Recently, we have shown that well-being can be achieved by resetting of the circadian clock and induction of robust catabolic circadian rhythms via timed feeding. In addition, the clock mechanism regulates metabolism and major metabolic proteins are key factors in the core clock mechanism. Therefore, it is necessary to increase our understanding of circadian regulation over metabolism and longevity and to design new therapies based on this regulation. This review will explore the present data in the field of circadian rhythms, ageing and metabolism.