Effect of sunlight exposure on cognitive function among depressed and non-depressed participants: a REGARDS cross-sectional study.
Effect of sunlight exposure on cognitive function among depressed and non-depressed participants: a REGARDS cross-sectional study.
复制标题
DOI：
10.1186/1476-069x-8-34
复制
发表时间：
2009-07-28
期刊：
影响因子：
--
通讯作者：
Sathiakumar N
中科院分区：
文献类型：
--
作者：
Kent ST;McClure LA;Crosson WL;Arnett DK;Wadley VG;Sathiakumar N
阳光对情绪影响的可能生理原因是通过视交叉上核，5-羟色胺和褪黑素的调节及其与抑郁的联系证明了这一点。这些途径中涉及的认知功能可能会受到阳光照射的潜在影响。我们评估了阳光暴露量(即日晒)是否会影响认知功能，并考察了季节对这种关系的影响。我们从一项对45岁以上的黑人和白人进行的全国性队列研究中获得了16,800名参与者在居民区的日照数据。认知障碍使用有效的六项筛查问卷进行评估，抑郁状态使用流行病学研究中心抑郁量表进行评估。采用Logistic回归分析，找出同一天或两周的平均日照时间是否与认知功能有关，以及这种关系是否因抑郁状态而异。在抑郁的参与者中，发现阳光暴露和认知功能之间存在剂量-反应关系，较低的阳光水平与认知状态受损有关(优势比=2.58；95%可信区间1.43-6.69)。虽然季节和日照都与认知功能相关，但在控制了它们的联合影响后，它们与认知障碍之间仍然存在显著的关系。这项研究使用了一种新的数据来源，发现了减少暴露在阳光下和增加认知障碍的可能性之间的联系。我们是第一个研究两周暴露在阳光下对认知的影响的人，也是第一个在大规模队列研究中观察阳光对认知影响的人。
Possible physiological causes for the effect of sunlight on mood are through the suprachiasmatic nuclei and evidenced by serotonin and melatonin regulation and its associations with depression. Cognitive function involved in these same pathways may potentially be affected by sunlight exposure. We evaluated whether the amount of sunlight exposure (i.e. insolation) affects cognitive function and examined the effect of season on this relationship. We obtained insolation data for residential regions of 16,800 participants from a national cohort study of blacks and whites, aged 45+. Cognitive impairment was assessed using a validated six-item screener questionnaire and depression status was assessed using the Center for Epidemiologic Studies Depression Scale. Logistic regression was used to find whether same-day or two-week average sunlight exposure was related to cognitive function and whether this relationship differed by depression status. Among depressed participants, a dose-response relationship was found between sunlight exposure and cognitive function, with lower levels of sunlight associated with impaired cognitive status (odds ratio = 2.58; 95% CI 1.43–6.69). While both season and sunlight were correlated with cognitive function, a significant relation remained between each of them and cognitive impairment after controlling for their joint effects. The study found an association between decreased exposure to sunlight and increased probability of cognitive impairment using a novel data source. We are the first to examine the effects of two-week exposure to sunlight on cognition, as well as the first to look at sunlight's effects on cognition in a large cohort study.