Filling-in after focal loss of photoreceptors in rat retina
Filling-in after focal loss of photoreceptors in rat retina
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DOI：
10.1006/exer.1998.0628
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发表时间：
1999-04-01
影响因子：
3.4
通讯作者：
van Norren, D
中科院分区：
文献类型：
--
作者：
Busch, EM;Gorgels, TGMF;van Norren, D
我们研究了在6个月的时间跨度在大鼠视网膜孤立的光感受器病变的命运。用仔细选择的UV-A（380 nm）剂量，在200、400或800 μ m宽的明显分界区域中引起光感受器的完全丧失，而对其他视网膜层没有可见的损伤。照射后1天，所有视杆细胞均固缩。三周后，几乎所有受损的感光细胞都被移除。随着周围的光感受器迁移到病变部位，病变部位的大小减小。外节尖端向内移动了200 μ m，但在外核层的最内层的核向内移动了大幅less. The距离在其中的光感受器迁移增加病变的大小，但只有200 μ m的缺陷被完全填充的水平上的外节。照射后3周至6个月，病变大小没有进一步减小。我们的结论是，局部损失后的感光细胞的毗邻感光细胞迅速转移到病变区域，但完全填充仅限于非常小的病变。(C)北京：科学出版社.
We investigated the fate of isolated photoreceptor lesions in rat retina over a time span of 6 months. With a carefully selected dose of UV-A (380 nm) a complete loss of photoreceptors was caused in sharply demarcated areas of 200, 400 or 800 mu m wide, without visible damage to other retinal layers. One day after irradiation, all rods were pyknotic. Three weeks later practically all damaged photoreceptors were removed. The size of the lesion had decreased as the surrounding photoreceptors had migrated into the lesion. The outer segment tips had moved inwards up to 200 mu m, but the innermost nuclei in the outer nuclear layer had moved inwards substantially less. The distance over which the photoreceptors migrated increased with lesion size, but only 200 mu m defects were filled-in completely on the level of the outer segments. Between three weeks and six months after irradiation, no further decrease in lesion size occurred. We conclude that after local loss of photoreceptor cells the bordering photoreceptors rapidly shift into the lesion area, but complete filling-in is limited to very small lesions. (C) 1999 Academic Press.