High levels of the soluble form of CD30 molecule in rheumatoid arthritis (RA) are expression of CD30+ T cell involvement in the inflamed joints
High levels of the soluble form of CD30 molecule in rheumatoid arthritis (RA) are expression of CD30+ T cell involvement in the inflamed joints
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DOI：
10.1111/j.1365-2249.1995.tb03851.x
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发表时间：
1995-12
影响因子：
4.6
通讯作者：
R. Gerli;C. Muscat;O. Bistoni;B. Falini;C. Tomassini;E. Agea;R. Tognellini;P. Biagini;A. Bertotto
中科院分区：
文献类型：
--
作者：
R. Gerli;C. Muscat;O. Bistoni;B. Falini;C. Tomassini;E. Agea;R. Tognellini;P. Biagini;A. Bertotto
CD30是由Th2型淋巴因子生成T细胞激活后表达的表面分子。表达CD30‐的活化T细胞释放一种可溶的分子形式，可以在体外和体内检测到。在本研究中，在RA患者的外周血和滑液中发现了高水平的可溶性CD30。然而，CD30+ CD3+细胞，CD4+或CD8+，在RA患者的滑液中显著存在，但在外周血中不存在。活动性RA患者血清可溶性CD30值高于非活动性RA患者，且与类风湿因子血清滴度直接相关。这些数据有力地支持CD30+ T细胞参与类风湿滑膜炎的免疫过程，并可能提示Th2型细胞因子分泌T细胞与类风湿滑膜炎病理反应之间的关系。
The CD30 is a surface molecule expressed by Th2‐type lymphokine‐producitig T cells upon activation. CD30‐expressing activated T cells release a soluble form of the molecule, which can be detectable both in vitro and in vivo. In the present study, high levels of soluble CD30 were found in peripheral blood and synovial fluid from patients with RA. However, CD30+ CD3+ cells, either CD4+ or CD8+, were significantly present in synovial fluid, but not in peripheral blood, of RA patients. Serum values of soluble CD30 were higher in active than inactive RA patients and directly correlated with rheumatoid factor serum titres. These data strongly support an involvement of CD30+ T cells in the immune processes of rheumatoid synovitis, and may suggest a relationship between Th2‐type cytokine‐secreting T cells and the pathological response in RA.