Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing
Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing
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DOI：
10.2217/nnm-2016-0084
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发表时间：
2016-08-01
期刊：
影响因子：
5.5
通讯作者：
Saunders, Margaret
中科院分区：
文献类型：
--
作者：
Barbour, Michele E.;Maddocks, Sarah E.;Saunders, Margaret
目的：研究六偏磷氯己定(CHX-HMP)作为创面护理材料的持久性抗菌涂层。材料与方法：采用CHX-HMP作为创面护理材料涂层，并与二葡萄糖酸氯己定材料进行抗菌效果、毒性及创面封闭等方面的比较。结果：实验材料和商品材料在第1、3、7天均能观察到抑菌效果。CHX-HMP包衣材料对人胎盘细胞的毒性作用小于市售洗必泰敷料。Pluronic凝胶中的CHX-HMP没有延迟愈合，但减少了粪肠球菌对伤口的定植。结论：CHX-HMP可作为创面护理材料的有效成分，具有持久的抗菌效果，比二葡萄糖酸氯己定材料毒性低，减少创面定植而不影响闭合。
Aim: In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. Materials & methods: CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Results: Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by E. faecalis. Conclusion: CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure.