OVERREPLICATION AND RECOMBINATION OF DNA IN HIGHER EUKARYOTES - POTENTIAL CONSEQUENCES AND BIOLOGICAL IMPLICATIONS
OVERREPLICATION AND RECOMBINATION OF DNA IN HIGHER EUKARYOTES - POTENTIAL CONSEQUENCES AND BIOLOGICAL IMPLICATIONS
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DOI：
10.1073/pnas.83.7.2157
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发表时间：
1986-04-01
影响因子：
11.1
通讯作者：
JOHNSTON, RN
中科院分区：
文献类型：
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作者：
SCHIMKE, RT;SHERWOOD, SW;JOHNSTON, RN
我们建议，在忠实复制的复杂的染色体的高等真核生物的一个基本问题是适当的控制的数量和时间的多个启动复制单染色体上。当复制模式被各种试剂中的任何一种破坏时，可以发生DNA的过度复制。我们提出了一个模型，占产生了各种各样的染色体畸变重排，导致从各种方式，其中过度复制链可以进行重组。我们还讨论了高等真核生物染色体变异的产生的某些影响，因为它们可能与癌症化疗，癌症进展，衰老和快速物种进化有关。
We propose that a fundamental problem in the faithful replication of complex chromsomes of higher eukaryotes is the proper control of both the number and timing of the multiple initiations of replication on single chromosomes. When replications patterns are disrupted by any of a variety of agents, overreplication of DNA can occur. We propose a model that accounts for the generation of a wide variety of chromosomal aberrations-rearrangement, resulting from the various ways in which the overreplicated strands can undergo recombination. We also discuss certain implications of the generation of chromosomal alterations in higher eukaryotes as they may relate to cancer chemotherapy, cancer progression, aging, and rapid speciation-evolution.