Periodontal treatment in patients with chronic kidney disease: a pilot study
Periodontal treatment in patients with chronic kidney disease: a pilot study
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DOI：
10.1111/jre.12390
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发表时间：
2017-04-01
影响因子：
3.5
通讯作者：
Fischer, R. G.
中科院分区：
文献类型：
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作者：
Almeida, S.;Figueredo, C. M.;Fischer, R. G.
背景和方法本试验性队列研究评价了牙周治疗对透析前慢性肾脏病（CKD）患者的肾功能、代谢标志物和非对称二甲基精氨酸（ADMA）的影响，这些患者表现为慢性牙周炎。材料和方法选择了26例CKD和重度慢性牙周炎患者。牙周参数包括菌斑指数、探诊出血、探诊袋深度和临床附着水平。在基线、牙周治疗后90和180 d评估肾小球滤过率（eGFR）、甘油三酯、总胆固醇、白蛋白和ADMA水平。结果牙周治疗后180 d，牙周临床指标均明显改善（p < 0.05）。中位值有显著改善（25%; 75%）eGFR从34.6从基线的（27; 44.7）mL/min/1.73 m（2）到第90天的37.6（29.7; 57）mL/min/1.73 m（2），和到第180天的37.6（28.6; 56）mL/min/1.73 m（2）（p < 0.05）。牙周治疗后180 d ADMA水平显著降低。没有显着差异，观察比较基线和180 d后牙周treatment.ConclusionsThe结果点肾脏疾病与内皮功能障碍和牙周炎的链接，表明牙周治疗可能是有益的CKD的过程中的代谢标志物的中位数。
Background and ObjectiveThis pilot cohort study evaluated the effect of periodontal treatment on renal function, metabolic markers and asymmetric dimethylarginine (ADMA) in patients with pre-dialysis chronic kidney disease (CKD) presenting chronic periodontitis.Material and MethodsTwenty-six patients with CKD and severe chronic periodontitis were selected. Periodontal parameters included plaque index, bleeding on probing, probing pocket depth and clinical attachment level. Estimated glomerular filtration rate (eGFR), triglycerides, total cholesterol, albumin and ADMA levels were evaluated at baseline, 90 and 180 d after periodontal therapy. eGFR was evaluated by the Modification of Diet in Renal Disease equation.ResultsAll periodontal clinical parameters significantly improved (p < 0.05) 180 d after periodontal therapy. There was a significant improvement on the median values (25%; 75% percentiles) of eGFR from 34.6 (27; 44.7) mL/min/1.73 m(2) on baseline to 37.6 (29.7; 57) mL/min/1.73 m(2) on day 90, and to 37.6 (28.6; 56) mL/min/1.73 m(2) (p < 0.05) on day 180. ADMA levels significantly reduced 180 d after periodontal treatment. No significant differences were observed at the median values of metabolic markers comparing baseline and 180 d after periodontal treatment.ConclusionsThe results point to a link of kidney disease with endothelium dysfunction and periodontitis, suggesting that periodontal treatment may be beneficial to the course of CKD.