Girls' preferences for HPV vaccination: A discrete choice experiment
Girls' preferences for HPV vaccination: A discrete choice experiment
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DOI：
10.1016/j.vaccine.2010.08.001
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发表时间：
2010-09-24
期刊：
影响因子：
5.5
通讯作者：
Korfage, Ida J.
中科院分区：
文献类型：
--
作者：
de Bekker-Grob, Esther W.;Hofman, Robine;Korfage, Ida J.
一个离散选择实验的开发，以调查如果12-16岁的女孩之间的人乳头瘤病毒（HPV）疫苗接种的各个方面进行权衡，并得出女孩的这些特征的相对权重。事实证明，对宫颈癌的保护程度、保护持续时间、副作用风险和疫苗接种年龄都会影响女孩对HPV疫苗接种的偏好。我们发现，女孩愿意放弃38%的宫颈癌保护，以获得终身保护，而不是6年的保护期，或者17%的人愿意获得HPV疫苗接种，每75万人中有1人，而不是每15万人中有1人的严重副作用风险。我们的结论是，女孩确实在保护程度和其他疫苗特性之间进行了权衡，如果女孩获得关于宫颈癌保护程度、保护持续时间和严重副作用风险的新的循证信息，HPV疫苗接种的情况可能会发生很大变化。(C)2010爱思唯尔有限公司版权所有。
A discrete choice experiment was developed to investigate if girls aged 12-16 years make trade-offs between various aspects of human papillomavirus (HPV) vaccination, and to elicit the relative weight that girls' place on these characteristics. Degree of protection against cervical cancer, protection duration, risk of side-effects, and age of vaccination, all proved to influence girls' preferences for HPV vaccination. We found that girls were willing to trade-off 38% protection against cervical cancer to obtain a lifetime protection instead of a protection duration of 6 years, or 17% to obtain an HPV vaccination with a 1 per 750,000 instead of 1 per 150,000 risk of serious side-effects. We conclude that girls indeed made a trade-off between degree of protection and other vaccine characteristics, and that uptake of HPV vaccination may change considerably if girls are supplied with new evidence-based information about the degree of protection against cervical cancer, the protection duration, and the risk of serious side-effects. (C) 2010 Elsevier Ltd. All rights reserved.