Abnormal functional connectivity of the anterior cingulate cortex subregions mediates the association between anhedonia and sleep quality in major depressive disorder
Abnormal functional connectivity of the anterior cingulate cortex subregions mediates the association between anhedonia and sleep quality in major depressive disorder
复制标题
前扣带皮层亚区域的异常功能连接介导重度抑郁症的快感缺乏与睡眠质量之间的关联
DOI：
10.1016/j.jad.2021.09.104
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发表时间：
2021-10-09
影响因子：
6.6
通讯作者：
Zhang，Chen
中科院分区：
文献类型：
--
作者：
Wu，Zenan;Fang，Xinyu;Zhang，Chen
背景前扣带皮层（anterior cingulate cortex，ACC）是抑郁症（major depression disorder，MDD）病理生理过程中的重要区域。然而，ACC亚区，快感缺乏和睡眠质量的功能改变之间的关系仍不清楚在MDDpatients.MethodsThe静息状态功能连接（rsFC）的ACC亚区进行了测量在41例首发药物初治MDD患者和63名健康对照者进行功能磁共振成像。使用双样本t检验检查组间差异。结果与健康对照组相比，MDD患者ACC各亚区到前默认模式网络（DMN）区域的rsFC增加，右膝下ACC到左楔前叶（PCUN）区域的rsFC减少，属于后DMN。MDD组的睡眠质量和完全性快感缺乏与某些rsFC相关，涉及角回（angular gyrus，ANG）和额上上级回（superior frontal gyrus，SFG）。更重要的是，rsFC之间的右膝周ACC和左SPG调解的关联性快感缺失和睡眠质量在MDD.LimitationsThe横截面设计和主观问卷assessment.ConclusionThese研究结果证实了ACC亚区的功能改变，揭示了ACC亚区在睡眠和奖励功能障碍的MDD的中介作用。
BackgroundThe anterior cingulate cortex (ACC) is a crucial region in the pathophysiology of major depressive disorder (MDD). However, the relationship between functional alterations of the ACC subregions, anhedonia and sleep quality remains unclear in MDD patients.MethodsThe resting-state functional connectivity (rsFC) of ACC subregions was measured in 41 first-episode medication-naïve MDD patients and 63 healthy controls who underwent functional magnetic resonance imaging. Between-group differences were examined using two-sample t-test. Furthermore, correlation and mediation analyses were carried out to investigate the relationships between the aberrant rsFC of ACC subregions, anhedonia and sleep quality in the patients and controls.ResultsCompared to healthy controls, the MDD patients exhibited increased rsFC of ACC subregions to areas of the anterior default mode network (DMN) and showed decreased rsFC of the right subgenual ACC to left precuneus (PCUN), which belongs to the posterior DMN. In MDD group, the sleep quality and consummatory anhedonia are correlated with some rsFC, which involves the angular gyrus (ANG) and superior frontal gyrus (SFG). More importantly, the rsFC between the right perigenual ACC and left SPG mediates the association between anhedonia and sleep quality in MDD.LimitationsThe cross-sectional design and the subjective questionaries for assessment.ConclusionThese findings confirm the functional alterations of the ACC subregions and reveal the mediating role of ACC subregions in sleep and reward dysfunction in MDD.