Evidence for 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene C4(LTC4) in the onset of labor.
Evidence for 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene C4(LTC4) in the onset of labor.
复制标题
5-羟基二十碳四烯酸 (5-HETE) 和白三烯 C4(LTC4) 在分娩开始时的证据。
DOI：
10.1111/j.1749-6632.1991.tb37879.x
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发表时间：
1991
影响因子：
5.2
通讯作者：
Walsh,SW
中科院分区：
文献类型：
--
作者：
Walsh,SW
结果在宫内手术时，5-HETE和LTC4的AF浓度分别为4.4 +/-0.8 ng/ml和2.5 +/-0.7 ng/ml。未检测到PGF 2 α水平。向母体输注吲哚美辛，虽然能有效抑制PGF 2 α水平，但不能预防2只动物的早产和阴道分娩。1只足月分娩猴的PGF2 α未升高。分娩前约1周，5-HETE和LTC4浓度在所有动物中急剧增加，与夜间分娩收缩模式相关。分娩期间的AF峰值浓度为5-HETE：40 +/-8 ng/ml，LTC4：20 +/-4 ng/ml，PGF2 α：5.4 +/-2.1 ng/ml。
ResultsAF concentrations at the time of intrauterine surgery were 4.4+/-0.8 ng/ml for 5-HETE and 2.5+/-0.7 ng/ml for LTC4. PGF2 alpha levels were nondetectable. Indomethacin infusion into the mother, although effective in suppressing PGF2 alpha levels, did not prevent the onset of premature labor and vaginal delivery in 2 animals. PGF2 alpha did not increase in 1 monkey with term labor. Approximately 1 week before delivery, 5-HETE and LTC4 concentrations increased sharply in all animals in association with a nocturnal pattern of labor contractions. Peak AF concentrations during labor were 5-HETE: 40+/-8 ng/ml, LTC4: 20+/-4 ng/ml, and PGF2 alpha: 5.4+/-2.1 ng/ml.