The hardship of obesity: a soft-wired hypothalamus
The hardship of obesity: a soft-wired hypothalamus
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DOI：
10.1038/nn1453
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发表时间：
2005-05-01
影响因子：
25
通讯作者：
Horvath, TL
中科院分区：
文献类型：
--
作者：
Horvath, TL
食物摄入和能量消耗是代谢表型的决定因素，并受CNS调节。虽然人类有一个平衡良好的自我平衡反馈回路，但肥胖和代谢紊乱正在迅速蔓延，并造成严重的发病率和死亡率。在过去的十年里，我们已经见证了对基本代谢过程的理解的重大进展，大脑回路决定了适当的，但不适当的行为和体液反应，以改变代谢线索仍然在很大程度上不明确。这篇综述总结了目前支持食物摄入和能量消耗的大脑解剖学知识，并讨论了突触可塑性等细胞机制，这些机制可能为开发成功的中枢疗法以对抗代谢紊乱（包括肥胖和糖尿病）提供线索。
Food intake and energy expenditure are determinants of metabolic phenotype and are regulated by the CNS. Although humans have a well-balanced homeostatic feedback loop, obesity and metabolic disorders are spreading rapidly and carry a heavy toll of morbidity and mortality. The past decade has witnessed major advances in the understanding of basic metabolic processes, the brain circuitry that determines appropriate and, but, inappropriate behavioral and humoral responses to changing metabolic cues remains largely ill defined. This review summarizes current knowledge of the brain anatomy that supports food intake and energy expenditure and discusses cellular mechanisms such as synaptic plasticity that may provide clues toward the development of successful central therapies to combat metabolic disorders, including obesity and diabetes.