The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life. A 34-year follow-up of the Northern Finland 1966 birth cohort
The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life. A 34-year follow-up of the Northern Finland 1966 birth cohort
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DOI：
10.1016/j.schres.2004.03.008
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发表时间：
2004-12-01
影响因子：
4.5
通讯作者：
Jones, PB
中科院分区：
文献类型：
--
作者：
Isohanni, M;Murray, GK;Jones, PB
精神分裂症的儿童先兆包括多种发育异常。早期和随后的偏离之间的连续性没有得到很好的描述。我们使用1岁(组队站立、行走和说话，获得膀胱和肠道控制能力)和16岁(在学校取得成功)的数据，研究了病前发育异常之间的关系。广义线性模型被用来检验成人精神病学诊断中的不同线性关联和趋势。在成年后患有精神分裂症或任何精神病的婴儿中，与较早的学习者相比，那些最晚学会站立的婴儿在16岁时在学校的运动和理论领域也更有可能表现不佳。这种影响不受遗传和围产期因素的影响。我们得出的结论是，生命第一年的早期发展偏差与16岁时较低的学习成绩有关。在患有精神病的儿童中，连续性比正常对照组和那些因非精神病精神障碍住院的儿童更强。这些发现符合这样的假设，即在精神分裂症之前的出生后大脑发育过程中存在神经素质。这支持了精神分裂症的纵向维度和寿命模型。(C)2004爱思唯尔B.V.保留所有权利。
Childhood precursors of schizophrenia include multiple abnormalities of development. Continuities between early and subsequent deviance are poorly characterised. We studied associations among premorbid developmental deviance using data at ages I year (teaming to stand, walk, and speak, attainment of bladder and bowel control) and 16 years (success at school). Generalised linear modelling was used to examine differential linear associations and trends across adult psychiatric diagnoses. In babies who, as adults, suffered schizophrenia or any psychosis, those who learned to stand latest were also more likely to perform poorly at school in both motor and theoretical domains at age 16 when-compared with earlier learners. The effect was independent of genetic and perinatal factors. We conclude that the early developmental deviation in the first year of life is associated with lower school performance at age 16. Developmental. continuity among,children who develop psychoses was stronger than among normal controls and those hospitalized for nonpsychotic psychiatric disorder. These findings are in line with the hypothesis that a neural diathesis is present during postnatal brain development before schizophrenia. this supports the longitudinal dimension and life span models of schizophrenia. (C) 2004 Elsevier B.V. All rights reserved.