CLINICAL DRUG-RESISTANT FALCIPARUM-MALARIA ACQUIRED FROM CULTURED PARASITES
CLINICAL DRUG-RESISTANT FALCIPARUM-MALARIA ACQUIRED FROM CULTURED PARASITES
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DOI：
10.4269/ajtmh.1981.30.523
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发表时间：
1981-01-01
影响因子：
3.3
通讯作者：
CARLIN, JM
中科院分区：
文献类型：
--
作者：
JENSEN, JB;CAPPS, TC;CARLIN, JM
这是第一次报告感染恶性疟原虫[人类疟疾寄生虫]获得这些寄生虫的连续培养。所涉及的菌株FCR3最初分离自西非冈比亚，并且最初在体外对氯喹敏感。经过近4年的连续培养，没有氯喹的压力，它成为耐氯喹在体外和体内，证明了失败的预防和治疗方案，以控制意外接种寄生虫感染的红细胞。
This is the 1st reported infection with P. falciparum [human malaria parasite] acquired from continuous cultures of these parasites. The strain involved, FCR3, was originally isolated from The Gambia, West Africa, and was initially sensitive to chloroquine in vitro. After nearly 4 yr of continuous culture without chloroquine pressure, it became resistant to chloroquine in vitro and in vivo, as demonstrated by the failure of both prophylactic and therapeutic regimens to control an accidental inoculation of parasite-infected erythrocytes.