Clinicopathology of recurrent hepatocellular carcinomas after radiofrequency ablation treated with salvage surgery
Clinicopathology of recurrent hepatocellular carcinomas after radiofrequency ablation treated with salvage surgery
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DOI：
10.1111/hepr.12223
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发表时间：
2014-10-01
影响因子：
4.2
通讯作者：
Suzuki, Yasuyuki
中科院分区：
文献类型：
--
作者：
Yamamoto, Naoki;Okano, Keiichi;Suzuki, Yasuyuki
目的射频消融（RFA）是小肝细胞癌（HCC）的有效标准局部治疗。然而，RFA 后的局部复发和/或肿瘤种植仍然是主要问题。为了更好地了解潜在因素，我们阐明了 RFA 治疗后复发 HCC 的临床病理特征。方法这项回顾性研究包括 21 名因 RFA 后 HCC 疾病复发而接受手术切除的患者。 Clinicopathological findings, including patterns of recurrence, immunohistochemical expression of proliferation markers (Ki-67 and p27(Kip1)) and survival outcome were assessed.ResultsThe median time interval after RFA until the diagnosis of intrahepatic and/or extrahepatic tumor progression was 12months (range, 3-84). Radical surgical resection was attempted for intrahepatic local recurrence in 16 patients (18 lesions), for peritoneal dissemination in four, for lymph node metastases in three and for adrenal metastasis in two. 21 名患者中有 14 名 (67%) 的复发性 HCC 经组织学诊断为低分化型。他们的平均 Ki-67 和 p27(Kip1) 标记指数显着较高 (P=0.020) 和较低 (P
AimRadiofrequency ablation (RFA) is an effective standard local therapy for small hepatocellular carcinoma (HCC). However, local recurrence and/or tumor seeding after RFA remain major problems. For better understanding of underlying factors, we clarified clinicopathological features of recurrent HCC treated with RFA.MethodsThis retrospective study included 21 patients who underwent surgical resection for HCC disease recurrence after RFA. Clinicopathological findings, including patterns of recurrence, immunohistochemical expression of proliferation markers (Ki-67 and p27(Kip1)) and survival outcome were assessed.ResultsThe median time interval after RFA until the diagnosis of intrahepatic and/or extrahepatic tumor progression was 12months (range, 3-84). Radical surgical resection was attempted for intrahepatic local recurrence in 16 patients (18 lesions), for peritoneal dissemination in four, for lymph node metastases in three and for adrenal metastasis in two. In 14 of the 21 (67%) patients, the recurrent HCC were histologically diagnosed as of poorly differentiated type. Their average Ki-67 and p27(Kip1) labeling indices were significantly higher (P=0.020) and lower (P