Specificity Proteins (SP) and Krüppel-like Factors (KLF) in Liver Physiology and Pathology.
Specificity Proteins (SP) and Krüppel-like Factors (KLF) in Liver Physiology and Pathology.
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DOI：
10.3390/ijms24054682
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发表时间：
2023-02-28
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
肝脏作为一个中心枢纽，控制着从代谢到异生物质解毒的几个基本生理过程。在细胞水平上，这些多效性功能通过肝细胞中的转录调节来促进。肝细胞功能及其转录调控机制的缺陷对肝功能产生不利影响，导致肝脏疾病的发展。近年来，酒精摄入量增加和西方饮食也导致易患肝病的人数显着增加。肝病是全球死亡的主要原因之一，在全球范围内造成约200万人死亡。了解肝细胞的转录机制和基因调控是必不可少的描绘疾病进展过程中的病理生理。本文综述了锌指家族转录因子特异性蛋白（SP）和Krüppel样因子（KLF）在肝细胞生理功能中的作用，以及它们如何参与肝脏疾病的发生和发展。
The liver acts as a central hub that controls several essential physiological processes ranging from metabolism to detoxification of xenobiotics. At the cellular level, these pleiotropic functions are facilitated through transcriptional regulation in hepatocytes. Defects in hepatocyte function and its transcriptional regulatory mechanisms have a detrimental influence on liver function leading to the development of hepatic diseases. In recent years, increased intake of alcohol and western diet also resulted in a significantly increasing number of people predisposed to the incidence of hepatic diseases. Liver diseases constitute one of the serious contributors to global deaths, constituting the cause of approximately two million deaths worldwide. Understanding hepatocyte transcriptional mechanisms and gene regulation is essential to delineate pathophysiology during disease progression. The current review summarizes the contribution of a family of zinc finger family transcription factors, named specificity protein (SP) and Krüppel-like factors (KLF), in physiological hepatocyte functions, as well as how they are involved in the onset and development of hepatic diseases.
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影响因子：
7.7
作者：
Bell-Anderson KS;Funnell AP;Williams H;Mat Jusoh H;Scully T;Lim WF;Burdach JG;Mak KS;Knights AJ;Hoy AJ;Nicholas HR;Sainsbury A;Turner N;Pearson RC;Crossley M
通讯作者：
Crossley M
影响因子：
5.6
作者：
Xie X;Jiang J;Ye W;Chen R;Deng Y;Wen J
通讯作者：
Wen J
ZBP-89 和 Sp1 有助于肝细胞癌细胞中的 Bak 表达。
影响因子：
3.8
作者：
Kong X;Xu P;Cai WJ;Wang HG;Li BB;Huang GL;He ZW;Chen G;Ye CG
通讯作者：
Ye CG
影响因子：
5.6
作者：
Chang HM;Liao YW;Chiang CH;Chen YJ;Lai YH;Chang YL;Chen HL;Jeng SY;Hsieh JH;Peng CH;Li HY;Chien Y;Chen SY;Chen LK;Huo TI
通讯作者：
Huo TI
DOI：
10.1007/978-1-0716-2249-0_11
发表时间：
2022
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
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作者：
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