Sensitivity and specificity of CA242 in gastro-intestinal cancer. A comparison with CEA, CA50 and CA 19-9.
Sensitivity and specificity of CA242 in gastro-intestinal cancer. A comparison with CEA, CA50 and CA 19-9.
复制标题
Ca242在胃肠癌中的敏感性和特异性。与CEA，CA50和CA 19-9的比较。
DOI：
10.1038/bjc.1992.44
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发表时间：
1992-02
影响因子：
8.8
通讯作者：
Lindholm, L
中科院分区：
文献类型：
--
作者：
Nilsson, O;Johansson, C;Glimelius, B;Persson, B;Norgaard-Pedersen, B;Andren-Sandberg, A;Lindholm, L
建立了一种新的肿瘤相关表位CA 242的血清学定量检测方法，并用于测定CA 242在胃肠道肿瘤中的敏感性和特异性。CA 242检测显示出比CA 50（和CA 19-9）更好的肿瘤特异性。这在良性肝胆疾病中最为明显。在结肠直肠癌Dukes A、B和C中，在90%特异性临界水平下，CA 242的灵敏度约为CA 50的3倍，而在胰腺癌中，CA 242和CA 50的灵敏度相似。CA 242独立于CEA表达，CEA和CA 242的组合在结肠直肠癌中比仅使用其中一种标记物的灵敏度高得多。这在Dukes A和Dukes B患者中最为明显。CA 242是一种具有潜在临床应用价值的新型肿瘤标志物，尤其是在结肠直肠癌中。
A serological assay for the quantitative determination of the novel tumour-associated epitope CA242 was developed and used for determination of sensitivity and specificity of CA242 in gastrointestinal cancer. The CA242 assay showed a better tumour specificity than CA50 (and CA 19-9). This was most noticeable in benign hepatobiliary disease. The sensitivity at 90% specificity cut-off level was approximately three times higher for CA242 compared to CA50 in colo-rectal cancer Dukes A, B and C, while in pancreatic cancer the sensitivity of CA242 and CA50 was similar. CA242 was expressed independently of CEA, and the combination of CEA and CA242 gave in colo-rectal cancer considerably higher sensitivity than the use of only one of the markers. This was most pronounced in Dukes A and Dukes B patients. CA242 is a novel tumour marker of potential clinical use, particularly in colo-rectal cancer.