SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation.
SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation.
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DOI：
10.1016/j.jaip.2017.11.023
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Phillips EJ
中科院分区：
文献类型：
--
作者：
White KD;Abe R;Ardern-Jones M;Beachkofsky T;Bouchard C;Carleton B;Chodosh J;Cibotti R;Davis R;Denny JC;Dodiuk-Gad RP;Ergen EN;Goldman JL;Holmes JH 4th;Hung SI;Lacouture ME;Lehloenya RJ;Mallal S;Manolio TA;Micheletti RG;Mitchell CM;Mockenhaupt M;Ostrov DA;Pavlos R;Pirmohamed M;Pope E;Redwood A;Rosenbach M;Rosenblum MD;Roujeau JC;Saavedra AP;Saeed HN;Struewing JP;Sueki H;Sukasem C;Sung C;Trubiano JA;Weintraub J;Wheatley LM;Williams KB;Worley B;Chung WH;Shear NH;Phillips EJ
史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症(SJS/TEN)是一种由免疫调节、通常由药物引起的危及生命的疾病，对个人、家庭和社会造成很高的负担，年发病率为1-5/100万。为了显著降低短期和长期发病率和死亡率，并促进临床护理和研究，需要多个内科、外科、行为学和基础科学学科的协调。2017年3月2日，在美国皮肤病学会年会之前，举行了一次由研究人员推动的会议，主要目的是在美国首次召集来自多个学科的临床医生和科学家参与SJS/TEN临床护理和基础科学研究。作为本次会议的成果，这篇文章概述了与SJS/TEN有关的知识现状和专家意见，内容涉及广泛的主题，包括流行病学和药物基因组学网络；临床管理和并发症；特殊人群，如儿科、老年人和孕妇；监管问题和电子健康记录；导致SJS/TEN的新病原体；药物基因组学和免疫病理学；以及患者的视角。目标包括维持一个持久和富有成效的多学科网络，这将大大促进科学进步，并转化为预防、早期诊断和管理SJS/TEN。©2017美国过敏症、哮喘和免疫学学会(J过敏性Clin免疫实践2018；6：38-69)
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a life-threatening, immunologically-mediated and usually drug-induced disease with a high burden to individuals, their families and society with an annual incidence of 1–5/1,000,000. To effect significant reduction in short- and long-term morbidity and mortality, and advance clinical care and research, coordination of multiple medical, surgical, behavioral, and basic scientific disciplines is required. On March 2, 2017 an investigator-driven meeting was held immediately prior to the American Academy of Dermatology Annual meeting for the central purpose of assembling, for the first time in the United States, clinicians and scientists from multiple disciplines involved in SJS/TEN clinical care and basic science research. As a product of this meeting, this article summarizes the current state of knowledge and expert opinion related to SJS/TEN covering a broad spectrum of topics including epidemiology and pharmacogenomic networks; clinical management and complications; special populations such as pediatrics, the elderly, and pregnant women; regulatory issues and the electronic health record; new agents that cause SJS/TEN; pharmacogenomics and immunopathogenesis; and the patient perspective. Goals include the maintenance of a durable and productive multidisciplinary network that will significantly further scientific progress and translation into prevention, early diagnosis, and management of SJS/TEN. ©2017 American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2018;6:38–69)
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
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发表时间：
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期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
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