Beneficial effects of dietary EGCG and voluntary exercise on behavior in an Alzheimer's disease mouse model.
Beneficial effects of dietary EGCG and voluntary exercise on behavior in an Alzheimer's disease mouse model.
复制标题
DOI：
10.3233/jad-140981
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Jennifer M. Walker;Diana Klakotskaia;Deepa Ajit;G. Weisman;W. Wood;G. Sun;P. Serfozo;Á. Simonyi-Á.-Simon
中科院分区：
文献类型：
--
作者：
Jennifer M. Walker;Diana Klakotskaia;Deepa Ajit;G. Weisman;W. Wood;G. Sun;P. Serfozo;Á. Simonyi-Á.-Simon
阿尔茨海默病（AD）是一种进行性的、年龄依赖性的神经退行性疾病，影响控制记忆和认知功能的特定脑区域。流行病学研究表明，运动和饮食中的抗氧化剂有利于降低AD风险。迄今为止，植物黄酮始终与预防与年龄有关的疾病有关。本研究调查了在2个月大时开始的4个月的轮跑运动的效果，以及饮用水中口服的绿色茶儿茶素（-）-表没食子儿茶素-3-没食子酸酯（EGCG）的效果（每日50 mg/kg）：（1）行为测量：在巴恩斯迷宫中的学习和记忆表现、筑巢、旷场、光-暗箱中的焦虑;和（2）TgCRND 8（Tg）小鼠中皮质和海马中的可溶性淀粉样蛋白-β（Aβ）水平。未经治疗的Tg小鼠表现出多动症，相对较差的筑巢行为，并在巴恩斯迷宫的空间学习的缺陷。EGCG和自愿运动，单独和组合，能够减弱筑巢和巴恩斯迷宫性能缺陷。此外，这些干预措施降低了皮质和海马中的可溶性Aβ1-42水平。这些结果，以及对人类的流行病学和临床研究，表明膳食多酚和运动可能对大脑健康和减缓AD的进展有有益的影响。
Alzheimer's disease (AD) is a progressive, age-dependent neurodegenerative disorder affecting specific brain regions that control memory and cognitive functions. Epidemiological studies suggest that exercise and dietary antioxidants are beneficial in reducing AD risk. To date, botanical flavonoids are consistently associated with the prevention of age-related diseases. The present study investigated the effects of 4 months of wheel-running exercise, initiated at 2-months of age, in conjunction with the effects of the green tea catechin (-)-epigallocatechin-3-gallate (EGCG) administered orally in the drinking water (50 mg/kg daily) on: (1) behavioral measures: learning and memory performance in the Barnes maze, nest building, open-field, anxiety in the light-dark box; and (2) soluble amyloid-β (Aβ) levels in the cortex and hippocampus in TgCRND8 (Tg) mice. Untreated Tg mice showed hyperactivity, relatively poor nest building behaviors, and deficits in spatial learning in the Barnes maze. Both EGCG and voluntary exercise, separately and in combination, were able to attenuate nest building and Barnes maze performance deficits. Additionally, these interventions lowered soluble Aβ1-42 levels in the cortex and hippocampus. These results, together with epidemiological and clinical studies in humans, suggest that dietary polyphenols and exercise may have beneficial effects on brain health and slow the progression of AD.