β-carboline alkaloids from a Korean tunicate Eudistoma sp.
β-carboline alkaloids from a Korean tunicate Eudistoma sp.
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DOI：
10.1021/np070064o
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发表时间：
2008-02-01
影响因子：
5.1
通讯作者：
Kang, Heonjoong
中科院分区：
文献类型：
--
作者：
Wang, Weihong;Nam, Sang-Jip;Kang, Heonjoong
Seven new ss-carboline-based metabolites, designated as eudistomins Y-1-Y-7 (1-7), were isolated from a tunicate of the genus Eudistoma collected near Tong-Yeong City, South Sea, Korea. These new metabolites differ from previously isolated marine metabolites due to the presence of a benzoyl group attached to the P-carboline nucleus at C-1. Eudistomins Y-1-Y-7 were evaluated for their antibacterial activity, and eudistomin Y-6 exhibited moderate antibacterial activity against Gram-positive bacteria Staphylococcus epidermis and Bacillus subtilis without cytotoxicity in the MTT assay at 100 mu M.
