Review of functional MRI in HIV: effects of aging and medication.
Review of functional MRI in HIV: effects of aging and medication.
复制标题
HIV 功能 MRI 综述：衰老和药物治疗的影响。
DOI：
10.1007/s13365-016-0483-y
复制
发表时间：
2017-02
影响因子：
3.2
通讯作者：
Vink M
中科院分区：
文献类型：
--
作者：
Hakkers CS;Arends JE;Barth RE;Du Plessis S;Hoepelman AI;Vink M
HIV相关性神经认知障碍（HAND）是HIV感染的常见并发症。有证据表明，这种疾病在进展到症状阶段之前就开始出现亚临床症状。血氧水平依赖（BOLD）功能磁共振成像已被证明是一个敏感的工具，以检测异常的脑功能在早期阶段，因此可能是有用的，以评估艾滋病毒感染对脑功能的影响。2015年6月进行了广泛的文献检索。纳入研究的合格标准如下：（1）与HIV阳性患者一起进行，（2）使用BOLD fMRI，（3）包括HIV阴性对照组。共纳入19项研究，包括931名受试者。当测试多个领域时，发现HIV阳性和阴性参与者之间的激活差异，即，注意力，（工作）记忆，尤其是执行功能。总体而言，HIV阳性患者在与任务相关的大脑区域表现出过度激活，尽管与对照组的表现相同。只有在最复杂的任务中，任务绩效才会降低。一些研究调查了衰老对功能磁共振成像的影响，其中大多数没有发现与艾滋病毒感染的相互作用。只有3项研究评价了联合抗逆转录病毒治疗（cART）对功能数据的影响，表明使用cART可增加激活。功能磁共振成像是一种敏感的仪器，可以检测艾滋病患者的细微认知变化。关于cART对fMRI的影响以及衰老对fMRI的影响，仍存在一些悬而未决的问题。本文的在线版本（doi：10.1007/s13365-016-0483-y）包含补充材料，可供授权用户使用。
HIV-associated neurocognitive disorder (HAND) is a frequently occurring comorbidity of HIV infection. Evidence suggests this condition starts subclinical before a progression to a symptomatic stage. Blood oxygenated level dependent (BOLD) fMRI has shown to be a sensitive tool to detect abnormal brain function in an early stage and might therefore be useful to evaluate the effect of HIV infection on brain function. An extensive literature search was performed in June 2015. Eligibility criteria for included studies were as follows: (1) conducting with HIV-positive patients, (2) using BOLD fMRI, and (3) including a HIV-negative control group. A total of 19 studies were included in the review including 931 participants. Differences in activation between HIV-positive and -negative participants were found when testing multiple domains, i.e., attention, (working) memory, and especially executive functioning. Overall, HIV-positive patients showed hyperactivation in task-related brain regions despite equal performances as controls. Task performance was degraded only for the most complex tasks. A few studies investigated the effect of aging on fMRI, and most of them found no interaction with HIV infection. Only three studies evaluated the effect of combination antiretroviral therapy (cART) on functional data suggesting an increase in activation with the use of cART. fMRI is a sensitive instrument to detect subtle cognitive changes in HIV patients. Open questions remain regarding the effects of cART on fMRI and the effects of aging on fMRI. The online version of this article (doi:10.1007/s13365-016-0483-y) contains supplementary material, which is available to authorized users.