AFFERENT-PROJECTIONS TO THE DORSAL THALAMUS OF THE RAT AS SHOWN BY RETROGRADE LECTIN TRANSPORT .2. THE MIDLINE NUCLEI
AFFERENT-PROJECTIONS TO THE DORSAL THALAMUS OF THE RAT AS SHOWN BY RETROGRADE LECTIN TRANSPORT .2. THE MIDLINE NUCLEI
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DOI：
10.1016/0361-9230(88)90227-4
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发表时间：
1988-08-01
影响因子：
3.8
通讯作者：
PHILLIPSON, OT
中科院分区：
文献类型：
--
作者：
CORNWALL, J;PHILLIPSON, OT
向支配伏核的丘脑中线细胞群的传入投射是通过逆行运输未结合的麦胚凝集素，然后用免疫细胞化学鉴定标记的细胞群来确定的。大量神经元分布于下丘脑视前内侧区、前部、腹内侧核、室周核、弓状核和后核，以及乳头状核和外侧核。丘脑吻侧注射后，外侧隔核、终纹床核和未定带内也可见标记细胞。在丘脑网状核的最顶端内侧，可见明显的局部标记。在吻部注射后的腹侧下丘脑区和丘脑中部注射后的丘脑周围皮质中发现了皮质标记。在脑干的中央灰质、被盖背外侧核、中缝、臂旁背侧和腹侧核以及孤束核均有标记。这些结果是在纹状体功能的背景下讨论的，特别是伏隔核，它是腹侧纹状体的一个组成部分。因此，丘脑中线核团可能提供了一个界面，在那里来自许多边缘区域和下丘脑核团的各种输入可以影响伏隔核的功能。对几个与纹状体功能和前额叶皮质直接相关的丘脑核团的传入进行了比较，结果表明，前脑从苍白球和下丘脑部位传入的丘脑具有清晰的地形图。一些传入神经元提出了可能降低网状激活系统参与基底节功能调节的具体途径。
Afferent projections to midline thalamic cell groups which innervate nucleus accumbens, were identified by the retrograde transport of unconjugated wheat germ agglutinin followed by the identification of labelled cell groups with immunocytochemistry. Large numbers of neurones were labelled in a variety of hypothalamic nuclei: principally in the medial preoptic area, anterior hypothalamic area, ventromedial, periventricular, arcuate and posterior hypothalamic nuclei, and in the supramammillary and lateral hypothalamic areas. Following rostral thalamic injections labelled cells were also found in the lateral septum, bed nucleus of the stria terminals, and zona incerta. Prominent and localised label was found in the nucleus reticularis of thalamus at its most rostral medial tip. Cortical label was found in the ventral subiculum following rostral injections, and in the perirhinal cortex following mid-thalamic injections. In the brainstem label was found in central gray, laterodorsal tegmental nucleus, raphe, dorsal and ventral parabranchial nuclei and nucleus of the tractus solitarius. The results are discussed in the context of striatal functoin, particularly the nucleus accumbens, which is a component of the ventral striatum. Thus, the midline thalamic nuclei may provide an interface where a variety of inputs from many limbic regions and hypothalamic nuclei can influence nucleus accumbens function. Comparison of afferents to several thalamic nuclei directly related to striatal function and the prefrontal cortex show, that forebrain thalamic afferents from pallidal and hypotalamic sites, are organised with an clear topography. Some afferents suggest specific routes which may alow the reticular activating system to participate in the regulation of basal ganglia function.