Ethical issues raised by whole genome sequencing
Ethical issues raised by whole genome sequencing
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DOI：
10.1016/j.bpg.2014.02.004
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发表时间：
2014-04-01
影响因子：
3.2
通讯作者：
Howard, Heidi Carmen
中科院分区：
文献类型：
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作者：
Pinxten, Wim;Howard, Heidi Carmen
虽然关于全基因组测序(WGS)和全外显子组测序(WES)的实施细节的讨论仍在继续，但遗传学家之间似乎已达成共识，即这些方法的广泛使用不仅不可避免，而且将是有益的[1]。然而，目前我们无法预测实施WGS和WES的全部用途、后果和影响。然而，已知的伦理问题，无论是在研究中还是在临床实践中，都是多样和复杂的，目前应该适当地解决。在这里，我们讨论WGS和WES的伦理方面，特别集中在三个重叠的主题上：(1)知情同意，(2)数据处理，和(3)结果返回。(C)2014爱思唯尔有限公司。保留所有权利。
While there is ongoing discussion about the details of implementation of whole genome sequencing (WGS) and whole exome sequencing (WES), there appears to be a consensus amongst geneticists that the widespread use of these approaches is not only inevitable, but will also be beneficial [1]. However, at the present time, we are unable to anticipate the full range of uses, consequences and impact of implementing WGS and WES. Nevertheless, the already known ethical issues, both in research and in clinical practice are diverse and complex and should be addressed properly presently. Herein, we discuss the ethical aspects of WGS and WES by particularly focussing on three overlapping themes: (1) informed consent, (2) data handling, and (3) the return of results. (C) 2014 Elsevier Ltd. All rights reserved.