Sensitivity of quantitative myocardial dynamic contrast-enhanced MRI to saturation pulse efficiency, noise and t1 measurement error: Comparison of nonlinearity correction methods
Sensitivity of quantitative myocardial dynamic contrast-enhanced MRI to saturation pulse efficiency, noise and t1 measurement error: Comparison of nonlinearity correction methods
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DOI：
10.1002/mrm.25726
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发表时间：
2016-03-01
影响因子：
3.3
通讯作者：
Buckley, David L.
中科院分区：
文献类型：
--
作者：
Broadbent, David A.;Biglands, John D.;Buckley, David L.
目的比较定量心肌动态对比增强（DCE） MRI中减少或纠正信号非线性的方法。方法对8名志愿者进行sce - mri模拟并获取数据。信号非线性使用双丸方法或基于模型的校正，使用质子密度加权成像（常规或双序列采集）或T-1数据（本地或书端）进行校正。模拟健康心肌和梗死心肌在3t时的扫描，包括噪声、饱和度缺陷和T-1测量误差。数据分析使用基于模型的反卷积与一室（单指数）模型。结果在志愿者中发现了不同方法之间的巨大差异。在模拟中，双丸法在实际饱和效率水平上是稳定的，但由于残余非线性而存在偏差。基于模型的方法在没有混杂误差源的情况下表现理想，并且通常对噪声或饱和度缺陷具有鲁棒性，但基于原生T-1的校正对后者高度敏感。所有方法都表明，在基线信号为零的过饱和水平以上，准确度有很大的变化。对于双序列方法，这在志愿者观察到的饱和效率上造成了很大的偏差。结论心肌DCE-MRI非线性校正方法的选择影响估计参数的准确性和精密度，尤其是在非理想饱和状态下。中华医学杂志，2016,25(5):391 - 391。(c) 2015 Wiley期刊公司
PurposeTo compare methods designed to minimize or correct signal nonlinearity in quantitative myocardial dynamic contrast-enhanced (DCE) MRI.MethodsDCE-MRI studies were simulated and data acquired in eight volunteers. Signal nonlinearity was corrected using either a dual-bolus approach or model-based correction using proton-density weighted imaging (conventional or dual-sequence acquisition) or T-1 data (native or bookend). Scanning of healthy and infarcted myocardium at 3 T was simulated, including noise, saturation imperfection and T-1 measurement error. Data were analyzed using model-based deconvolution with a one-compartment (mono-exponential) model.ResultsSubstantial variation between methods was demonstrated in volunteers. In simulations the dual-bolus method proved stable for realistic levels of saturation efficiency but demonstrated bias due to residual nonlinearity. Model-based methods performed ideally in the absence of confounding error sources and were generally robust to noise or saturation imperfection, except for native T-1 based correction which was highly sensitive to the latter. All methods demonstrated large variation in accuracy above an over-saturation level where baseline signal was nulled. For the dual-sequence approach this caused substantial bias at the saturation efficiencies observed in volunteers.ConclusionThe choice of nonlinearity correction method in myocardial DCE-MRI impacts on accuracy and precision of estimated parameters, particularly in the presence of nonideal saturation. Magn Reson Med 75:1290-1300, 2016. (c) 2015 Wiley Periodicals, Inc.