Asymmetric Synthesis of Hydroxylated Pyrrolidines, Piperidines and Related Bioactive Compounds: From N-Acyliminium Chemistry to N-α-Carbanion Chemistry
Asymmetric Synthesis of Hydroxylated Pyrrolidines, Piperidines and Related Bioactive Compounds: From N-Acyliminium Chemistry to N-α-Carbanion Chemistry
复制标题
DOI：
10.1055/s-2006-941565
复制
发表时间：
2006-05
期刊：
影响因子：
2
通讯作者：
Pei‐Qiang Huang
中科院分区：
文献类型：
--
作者：
Pei‐Qiang Huang
本文介绍了我们最近的研究进展，手性非外消旋环酰亚胺为基础的合成方法和互补的N-α-碳负离子为基础的合成方法的不对称合成天然存在的或药学上感兴趣的羟基化吡咯烷，2-吡咯烷酮，β-羟基-γ-氨基酸，以及它们的高级同系物;以及异吲哚啉-1-酮;特特拉姆酸和特特拉姆酸衍生物。
This account describes our recent studies on the development of chiral nonracemic cyclic imide-based synthetic methodology and the complementary N-α-carbanion synthon-based synthetic methodology for the asymmetric syntheses of naturally occurring or pharmaceutically interesting hydroxylated pyrrolidines, 2-pyrrolidinones, β-hydroxy-γ-amino acids, and their higher homologous; as well as isoindolin-1-ones; tetramic acid and tetramate derivatives.