Influence of voluntary exercise on hypothalamic norepinephrine
Influence of voluntary exercise on hypothalamic norepinephrine
复制标题
DOI：
10.1152/jappl.1998.85.3.962
复制
发表时间：
1998-09-01
影响因子：
3.3
通讯作者：
Jonsdottir, IH
中科院分区：
文献类型：
--
作者：
Lambert, GW;Jonsdottir, IH
我们将下丘脑组织和血浆中去甲肾上腺素、二羟基苯丙氨酸和二羟基苯乙二醇的测定与自愿跑步大鼠腹部脂肪的测量结合起来，研究运动训练、下丘脑和交感神经之间的关系。功能，和身体脂肪的储存。运动训练后下丘脑去甲肾上腺素、二羟基苯丙氨酸和二羟基苯乙二醇浓度降低（P < 0.01），且去甲肾上腺素的量与血浆去甲肾上腺素（r = 0.58, P < 0.05）和二羟基苯乙二醇（r = 0.65, P = 0.01）浓度呈正相关。运动训练导致腹部脂肪量减少（P < 0.01）。脂肪量与下丘脑去甲肾上腺素含量有很强的相关性（r = 0.83, P < 0.001）。动脉和下丘脑的去甲肾上腺素水平之间存在正相关关系，为下丘脑的去甲肾上腺素能神经元活动和交感神经功能之间的关联提供了推定证据。腹部脂肪团与下丘脑的去甲肾上腺素有关，这一观察结果提出了一种可能性，即体内脂肪储存的改变提供了一种连接下丘脑功能和交感神经系统活动的传入信号。
We combined hypothalamic tissue and plasma determinations of norepinephrine, dihydroxyphenylalanine, and dihydroxyphenylglycol with measurements of abdominal fat in voluntary running rats to examine the relationship among exercise training, hypothalamic and sympathetic nervous. function, and body fat stores. The hypothalamic concentrations of norepinephrine, dihydroxyphenylalanine, and dihydroxyphenylglycol were reduced after exercise training (P < 0.01), with the amount of norepinephrine being strongly associated with the plasma norepinephrine (r = 0.58, P < 0.05) and dihydroxy-phenylglycol (r = 0.65, P = 0.01) concentrations. Exercise training resulted in a diminution in abdominal fat mass (P < 0.01) A strong relationship existed between fat mass and hypothalamic norepinephrine content (r = 0.83, P < 0.001). The presence of a positive relationship between the arterial and hypothalamic norepinephrine levels provides presumptive evidence of an association between noradrenergic neuronal activity of the hypothalamus and sympathetic nervous function. The observation that abdominal fat mass is linked with norepinephrine in the hypothalamus raises the possibility that alterations in body fat stores provide an afferent signal linking hypothalamic function and the activity of the sympathetic nervous system.