Motor and nonmotor domains in the monkey dentate
Motor and nonmotor domains in the monkey dentate
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DOI：
10.1111/j.1749-6632.2002.tb07575.x
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Strick, PL
中科院分区：
文献类型：
--
作者：
Dum, RP;Li, C;Strick, PL
在过去的10年里，我们对小脑的组织和功能的概念发生了很大的变化。在最近的研究中，我们使用跨神经元病毒追踪技术证明灵长类动物的小脑的输出不仅通过丘脑投射到其经典的运动目标初级运动皮质，而且还投射到前额叶和后顶叶皮质的“非运动”区域。我们发现，投射到不同皮质区域的齿状神经元起源于核团的局部区域，我们称之为“输出通道”。为了比较投射到不同皮质目标的输出通道的位置，我们创建了一张齿状突起的展开图。这张展开的图显示，齿状输出通道被分成空间上分离的“运动”和“非运动”区域。运动域中的输出通道只针对大脑皮层的初级运动和运动前区域。这些通道位于齿状回的背侧。非运动区的输出通道投射到前额叶和后顶叶皮质区域。非运动区局限于齿状体内的腹侧部分。在最近的研究中，我们定义了一个独特的分子标记--单抗8B3。这似乎是对这两个领域的不同“识别”。综上所述，我们的结果表明，齿状输出是根据其皮质目标的功能能力来组织的。这种组织结构为齿状核提供了解剖学基础，不仅影响运动的控制，而且影响认知、高级执行和视觉空间功能。
Our concepts about the organization and functions of the cerebellum have changed substantially in the last 10 years. In recent studies, we used transneuronal virus tracing techniques to demonstrate that the output of the cerebellum of primates projects via the thalamus not only to its classical motor target, the primary motor cortex, but also to "nonmotor" cortical areas in the prefrontal and posterior parietal cortex. We found that dentate neurons projecting to different cortical areas originated from localized regions of the nucleus which we termed "output channels." To compare the locations of the output channels projecting to different cortical targets, we have created an unfolded map of the dentate. This unfolded map revealed that dentate output channels were segregated into spatially separate "motor" and "nonmotor" domains. The output channels in the motor domain exclusively targeted primary motor and premotor areas of the cerebral cortex. These channels were localized in the dorsal portion of the dentate. The output channels in the nonmotor domain projected to prefrontal and posterior parietal cortical areas. The nonmotor domain was confined to the ventral portion of the dentate. In recent studies, we defined a unique molecular marker, monoclonal antibody 8B3. which appears to differentially "recognize" these two domains. Taken together, our results suggest that dentate output is organized according to the functional capabilities of its cortical targets. This organization provides the dentate nucleus with the anatomical substrate to influence not only the control of movement, but also cognitive, higher-order executive and visuospatial functions.