Implementation of Pharmacogenetics at Cincinnati Children's Hospital Medical Center: Lessons Learned Over 14 Years of Personalizing Medicine
Implementation of Pharmacogenetics at Cincinnati Children's Hospital Medical Center: Lessons Learned Over 14 Years of Personalizing Medicine
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DOI：
10.1002/cpt.1165
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发表时间：
2019-01-01
影响因子：
6.7
通讯作者：
Glauser, Tracy A.
中科院分区：
文献类型：
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作者：
Ramsey, Laura B.;Prows, Cynthia A.;Glauser, Tracy A.
药物反应的显著个体间差异可导致药物不良反应（ADR）和医疗费用增加。基于ADR的流行率和越来越多的证据将遗传学和药代动力学变异性联系起来，辛辛那提儿童医院医学中心（CCHMC）于2004年推出了遗传药理学服务（GPS），自那时以来已经进行了25，000多次检测。在此，我们将描述该服务是如何开发、启动和更新的;它目前是如何使用的;以及学到的关键经验教训。
Significant interindividual variability in medication response can result in adverse drug reactions (ADRs) and increased healthcare costs. On the basis of ADR prevalence and mounting evidence linking genetics and pharmacokinetic variability, Cincinnati Children's Hospital Medical Center (CCHMC) launched the Genetic Pharmacology Service (GPS) in 2004 and has since performed >25,000 tests. Herein, we describe how the service developed, launched, and has been updated; how it is currently used; and key lessons learned.