TRANSFERRIN INDUCES MATURATION OF NEUTROPHIL GRANULOCYTE PRECURSORS INVITRO
TRANSFERRIN INDUCES MATURATION OF NEUTROPHIL GRANULOCYTE PRECURSORS INVITRO
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DOI：
10.1016/0145-2126(86)90073-1
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发表时间：
1986-01-01
影响因子：
2.7
通讯作者：
MAGE, MG
中科院分区：
文献类型：
--
作者：
EVANS, WH;WILSON, SM;MAGE, MG
先前的研究表明，豚鼠的透析血清含有一个因子，该因子诱导豚鼠粒细胞前体在体外形成成熟的嗜中性粒细胞。我们在这里表明，这种成熟诱导血清的活性主要与转铁蛋白有关。该活性不是特定于物种的，因为豚鼠和人类转铁蛋白都以这种能力同样很好地发挥作用。这些发现提出了转铁蛋白可以作为粒细胞成熟的生理调节剂的可能性。
Previous studies showed that dialyzed serum from guinea pigs contained a factor which induces guinea pig granulocyte precursors to form mature neutrophil granulocytes in vitro. We show here that this maturation inducing activity of serum is associated primarily with transferrin. This activity is not species specific since both guinea pig and human transferrin serve equally well in this capacity. These findings raise the possibility that transferrin could serve as a physiological regulator of granulocyte maturation.