High expression of CXCR3 is an independent prognostic factor in glioblastoma patients that promotes an invasive phenotype
High expression of CXCR3 is an independent prognostic factor in glioblastoma patients that promotes an invasive phenotype
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CXCR3的高表达是胶质母细胞瘤患者的独立预后因素，可促进侵袭性表型
DOI：
10.1007/s11060-014-1692-y
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发表时间：
2015-03-01
影响因子：
3.9
通讯作者：
Sun, Lihua
中科院分区：
文献类型：
--
作者：
Pu, Yi;Li, Shouwei;Sun, Lihua
趋化因子是一个小的肝素结合细胞因子超家族，通过与特定的跨膜G蛋白偶联受体相互作用，诱导白细胞迁移到炎症或损伤部位。目前，人们的注意力集中在趋化因子/趋化因子受体对及其促进肿瘤细胞迁移和血管生成的能力上。趋化因子受体CXCR3参与肿瘤转移，可作为判断预后的生物标记物。然而，其与原发性多形性胶质母细胞瘤(PGBM)临床病理特征的关系及其潜在的预后价值仍有待研究。在此，我们报告高表达CXCR3导致pGBM患者存活率较低。进一步分析表明，CXCR3可作为预测pGBM患者预后的独立生物标志物。此外，功能分析表明，CXCR3可诱导胶质瘤细胞的侵袭。因此，这一证据表明CXCR3是pGBM患者的一个独立的预后因素，并促进了侵袭性表型，这为多形性胶质母细胞瘤的治疗提供了一个新的潜在生物靶点。
Chemokines are a superfamily of small heparin-binding cytokines that induce leukocytes to migrate to sites of inflammation or injury through interacting with specific transmembrane G protein-coupled receptors. Currently, attention is focused on chemokine/chemokine receptor pairs and their ability to promote tumor cell migration and angiogenesis. The chemokine receptor CXCR3 is involved in tumor metastasis and is used as a prognostic biomarker. However, its relationship with the clinicopathological features of primary glioblastoma multiforme (pGBM) and its potential prognostic value have yet to be investigated. Here, we report that high CXCR3 expression conferred poor survival in pGBM patients. Further analysis showed that CXCR3 served as an independent prognostic biomarker for pGBM patients. In addition, functional assays indicated that CXCR3 induced glioma cell invasion. Therefore, this evidence indicates CXCR3 is an independent prognostic factor for pGBM patients and promotes an invasive phenotype, which suggests a new potential biotarget for glioblastoma multiforme therapy.