An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine.
An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine.
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大脑含血清素系统在 d-苯丙胺的运动作用中具有抑制作用。
DOI：
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发表时间：
1976
影响因子：
3.5
通讯作者：
S. Schanberg
中科院分区：
文献类型：
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作者：
Alan S. Hollister;G. Breese;Cynthia M. Kuhn;B. R. Cooper;S. Schanberg
D-苯丙胺诱发的运动活动被发现被食物剥夺、不含色氨酸的饮食、对氯苯丙氨酸和被认为能拮抗大脑中5-羟色胺受体的药物所增强。在注射D-苯丙胺前1小时给予L-色氨酸，可拮抗饥饿大鼠和饮食中不含色氨酸的大鼠对D-苯丙胺的增强反应。然而，色氨酸并不能阻止经对氯苯丙氨酸处理的动物对d-苯丙胺的增强反应。这些发现表明，在饥饿大鼠和无色氨酸饮食的大鼠中，色氨酸拮抗D-苯丙胺诱导的活性不是由于氨基酸的非特异性抑制作用。由于d-苯丙胺及其代谢物的积累不受任何增强其活性的处理的影响，d-苯丙胺代谢的变化似乎不太可能解释这些发现。本工作为5-羟色胺能纤维在d-苯丙胺的作用中发挥重要作用的观点提供了额外的支持。
Locomotor activity induced by d-amphetamine was found to be potentiated by food deprivation, a tryptophan-free diet, p-chlorophenylalanine and drugs proposed to antagonize serotonin receptors in brain. Administration of L-tryptophan 1 hour prior to d-amphetamine injection was found to antagonize the enhanced response to d-amphetamine in starved rats and in rats which had tryptophan removed from their diet. However, tryptophan did not block the potentiated response to d-amphetamine in animals pretreated with p-chlorophenylalanine. These findings suggested that the antagonism of d-amphetamine-induced activity by tryptophan in starved rats and rats fed a tryptophan-free diet was not due to a nonspecific depressant effect of the amino acid. Since accumulation of d-amphetamine and its metabolites was not affected by any of the treatments which enhanced its activity, it seems unlikely that an alteration in the metabolism of d-amphetamine can explain these findings. The present work provides additional support for the view that serotonergic fibers play an important role in the actions of d-amphetamine.