Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003-06
Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003-06
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DOI：
10.1093/eurheartj/ehq451
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发表时间：
2011-03-01
影响因子：
39.3
通讯作者：
Owen, Neville
中科院分区：
文献类型：
--
作者：
Healy, Genevieve N.;Matthews, Charles E.;Owen, Neville
目的 在发达经济体中，长时间久坐现象普遍存在，且与不良的心血管代谢风险状况和过早死亡相关。本研究探讨了客观评估的久坐时间以及久坐时间的中断（间断）与连续性心血管代谢和炎症风险生物标志物之间的关联，以及这些关联是否因性别、年龄和/或种族/族裔而有所不同。
方法与结果 对来自2003/04年和2005/06年美国国家健康与营养检查调查（NHANES）的4757名参与者（≥20岁）进行横断面分析。使用Actigraph加速度计得出久坐时间[＜每分钟100次计数（cpm）]以及久坐时间的中断情况。在排除包括中等到高强度运动在内的潜在混杂因素后，观察到久坐时间与腰围、高密度脂蛋白胆固醇、C - 反应蛋白、甘油三酯、胰岛素、胰岛素分泌指数（HOMA - %B）和胰岛素敏感性指数（HOMA - %S）之间存在有害的线性关联（趋势P＜0.05）。在排除潜在混杂因素和久坐时间的影响后，中断与腰围和C - 反应蛋白呈有益关联（趋势P＜0.05）。年龄、性别或种族/族裔在与生物标志物的关联方面存在有意义差异的证据有限。值得注意的例外情况是，久坐时间和中断与高密度脂蛋白胆固醇的关联存在性别差异，以及久坐时间与腰围的关联存在种族/族裔差异，在非西班牙裔白人中关联有害，在墨西哥裔美国人中无关联，在非西班牙裔黑人中有益。
结论 这些是关于长时间久坐与心血管代谢和炎症生物标志物有害关联的首批具有人群代表性的研究结果。研究结果表明，关于减少和打破久坐时间的临床交流和预防性健康信息可能对心血管疾病风险有益。
Aims Prolonged sedentary time is ubiquitous in developed economies and is associated with an adverse cardio-metabolic risk profile and premature mortality. This study examined the associations of objectively assessed sedentary time and breaks (interruptions) in sedentary time with continuous cardio-metabolic and inflammatory risk biomarkers, and whether these associations varied by sex, age, and/or race/ethnicity.Methods and results Cross-sectional analyses with 4757 participants (>= 20 years) from the 2003/04 and 2005/06 US National Health and Nutrition Examination Survey (NHANES). An Actigraph accelerometer was used to derive sedentary time [< 100 counts per minute (cpm)] and breaks in sedentary time. Independent of potential confounders, including moderate-to-vigorous exercise, detrimental linear associations (P for trends < 0.05) of sedentary time with waist circumference, HDL-cholesterol, C-reactive protein, triglycerides, insulin, HOMA-%B, and HOMA-%S were observed. Independent of potential confounders and sedentary time, breaks were beneficially associated with waist circumference and C-reactive protein (P for trends < 0.05). There was limited evidence of meaningful differences in associations with biomarkers by age, sex, or race/ethnicity. Notable exceptions were sex-differences in the associations of sedentary time and breaks with HDL-cholesterol, and race/ethnicity differences in the association of sedentary time with waist circumference with associations detrimental in non-Hispanic whites, null in Mexican Americans, and beneficial in non-Hispanic blacks.Conclusion These are the first population-representative findings on the deleterious associations of prolonged sedentary time with cardio-metabolic and inflammatory biomarkers. The findings suggest that clinical communications and preventive health messages on reducing and breaking up sedentary time may be beneficial for cardiovascular disease risk.