Human red cell antigens
Human red cell antigens
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人类红细胞抗原
作者：
M. Telen;T. Bolk
次要红细胞唾液酸糖蛋白-β和γ（也称为血型糖蛋白C）-被认为对红细胞的结构完整性很重要。分别在En（a-）和S-s-U-细胞中观察到的唾液酸糖蛋白α和δ的缺失导致细胞具有正常形态，但唾液酸糖蛋白β和γ的缺失与椭圆形红细胞增多症相关。然而，缺乏Gerbich（Ge）抗原但具有与β抗体反应的异常唾液酸糖蛋白的细胞具有正常形态。作者使用β特异性单克隆抗体来探索这种异常唾液酸糖蛋白的性质及其与其他膜蛋白的相互作用。由于免疫凝集素通常可利用的位点的其他分子的空间位阻，Ge‐Yus‐红细胞的β样唾液酸糖蛋白似乎与某些抗体反应不良。这种空间位阻不是由于与唾液酸糖蛋白α或δ或带3的单一相互作用。此外，其他分子的空间位阻不能解释这些细胞上Ge抗原的缺乏。
The minor red cell sialoglycoproteins‐beta and gamma (also known as glycophorin C)–are believed to be important to the structural integrity of red cells. The absence of sialoglycoproteins alpha and delta, as seen in En(a‐) and S‐s‐U‐ cells, respectively, results in cells with normal morphology, but the absence of sialoglycoproteins beta and gamma is associated with elliptocytosis. However, cells that lack Gerbich (Ge) antigens but have an abnormal sialoglycoprotein reactive with antibodies to beta have normal morphology. The authors used a monoclonal antibody specific for beta to explore the nature of this abnormal sialoglycoprotein and its interactions with other membrane proteins. The beta‐like sialoglycoprotein of Ge‐Yus‐ red cells appears to react poorly with some antibodies due to steric hindrance by other molecules of sites normally available to immune agglutinins. This steric hindrance is not due to a single interaction with either sialoglycoprotein alpha or delta or band 3. Furthermore, steric hindrance by other molecules does not account for the lack of Ge antigens on these cells.
影响因子：
20.3
作者：
Telen,MJ;Palker,TJ;Haynes,BF
通讯作者：
Haynes,BF