Multi-drug delivery and osteogenic performance of β-tricalcium phosphate/alginate composite microspheres
Multi-drug delivery and osteogenic performance of β-tricalcium phosphate/alginate composite microspheres
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DOI：
10.1080/00914037.2023.2250049
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发表时间：
2023-08
影响因子：
3.2
通讯作者：
Qingyun Fu;Zhenzhao Guo;Bo Dongyin;H. Ke;Su Ziyu;Weihong Jin;Z. Yu;Shulan Xu;Li Hong
中科院分区：
文献类型：
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作者：
Qingyun Fu;Zhenzhao Guo;Bo Dongyin;H. Ke;Su Ziyu;Weihong Jin;Z. Yu;Shulan Xu;Li Hong
摘要针对目前β-磷酸三钙/海藻酸钙微球多药缓释和骨形成系统研究的不足，对其多药释放动力学和成骨行为进行了研究。结果表明，不同载药量的微球均表现出早期突释现象，且载药量随微球粒径的减小而减小。体外细胞增殖和DEAD/LIVE染色表明微球具有良好的细胞相容性，体内实验表明微球具有良好的促进骨再生的能力。图形摘要
Abstract To address the insufficiencies in the systemic research of calcium phosphate/alginate (ALG) microspheres for multi-drug delivery and bone formation, this study investigated the multi-drug release kinetics and osteogenic behaviors of β-tricalcium phosphate/ALG microspheres. The results showed that different loaded drugs exhibited an early burst release phenomenon, and the drug loading capacity decreased as the microsphere particle size decreased. In vitro cell proliferation and dead/live staining demonstrated that the microspheres had excellent cytocompatibility, and in vivo experiments demonstrated the microspheres’ exceptional ability to enhance bone regeneration. Graphical Abstract