Estimation of single-generation sibling relationships based on DNA markers
Estimation of single-generation sibling relationships based on DNA markers
复制标题
DOI：
10.2307/1400594
复制
发表时间：
1999-06-01
影响因子：
1.4
通讯作者：
Field, C
中科院分区：
文献类型：
--
作者：
Almudevar, A;Field, C
提出了一种基于DNA标记数据推断单代生物样本的联合同胞关系的算法。该技术主要基于不相容原理，即，在DNA不相容的基础上系统地消除个体之间的假设亲属类型的过程。结果是所有遗传相容的兄弟姐妹分组的枚举，在没有其他个体可以添加到兄弟姐妹组的意义上，这是最大的。该技术是计算上可行的大样本中所使用的DNA标记给予足够的可变性。由此，我们根据分数将个体划分为兄弟群体。此外，我们推导出一些统计性质的同胞兼容性事件以及各种类型的错误概率与同胞识别。使用渔业数据说明了这些技术。
An algorithm for infering joint sibling relationships for a single generation sample of organisms based on DNA marker data is presented. The technique is based primarily on the exclusion principle, i.e., the process of systematically eliminating hypothetical kinship types between individuals in the basis of DNA incompatibility. The result is an enumeration of all genetically compatible sibling groupings, which is maximal in the sense that no other individual can be added to the sibling group. The technique is computationally feasible for large samples given enough variablility in the DNA markers used. From this, we construct a partition of the individuals into sibling groups based on a score. In addition, we derive some statistical properties of sibling compatibility events as well as various types of error probabilities associated with sibling identification. The techniques are illustrated using fisheries data.