Innate immune recognition of the microbiota promotes host-microbial symbiosis.
Innate immune recognition of the microbiota promotes host-microbial symbiosis.
复制标题
微生物群的先天免疫识别促进宿主-微生物共生。
作者：
传统上已知模式识别受体（PRR）在感染期间识别微生物分子以启动炎症反应。然而，PRR的配体并不是病原体独有的，并且在正常定殖期间由常驻微生物群大量产生。造成这种矛盾的机制仍然不清楚。最近的研究表明，来自微生物群的肠道细菌配体通过PRR发出信号，以促进宿主组织和免疫发育，并保护免受疾病的侵害。此外，来自无脊椎动物和脊椎动物模型的证据表明，先天免疫受体是促进微生物群长期定植所必需的。这种新兴的观点挑战了免疫学中的当前范式，并表明PRR可能已经进化，部分介导微生物共生体与其宿主之间的双向串扰。
Pattern recognition receptors (PRRs) are traditionally known to recognize microbial molecules during infection to initiate inflammatory responses. However, ligands for PRRs are not exclusive to pathogens, and are abundantly produced by the resident microbiota during normal colonization. Mechanism(s) that underlie this paradox have remained unclear. Recent studies reveal that gut bacterial ligands from the microbiota signal through PRRs to promote host tissue and immune development, and protection from disease. Furthermore, evidence from both invertebrate and vertebrate models reveals that innate immune receptors are required to promote long-term colonization by the microbiota. This emerging perspective challenges current paradigms in immunology, and suggests that PRRs may have evolved, in part, to mediate the bidirectional crosstalk between microbial symbionts and their hosts.
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影响因子：
6.7
作者：
Bischoff V;Vignal C;Duvic B;Boneca IG;Hoffmann JA;Royet J
通讯作者：
Royet J
DOI：
10.1073/pnas.1019378108
发表时间：
2011-03-29
影响因子：
11.1
作者：
Ichinohe, Takeshi;Pang, Iris K.;Iwasaki, Akiko
通讯作者：
Iwasaki, Akiko
影响因子：
30.3
作者：
Bates, Jennifer M.;Akerlund, Janie;Guillemin, Karen
通讯作者：
Guillemin, Karen
影响因子：
64.8
作者：
Bouskra, Djahida;Brezillon, Christophe;Eberl, Gerard
通讯作者：
Eberl, Gerard
DOI：
10.1073/pnas.1213110109
发表时间：
2012-11-20
影响因子：
11.1
作者：
Franzenburg, Soeren;Fraune, Sebastian;Bosch, Thomas C. G.
通讯作者：
Bosch, Thomas C. G.