Bone marrow transplantation for acute myelosclerosis
Bone marrow transplantation for acute myelosclerosis
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骨髓移植治疗急性骨髓硬化
作者：
J. Smith;H. Shulman;E. Thomas;A. Fefer;C. Buckner
4例急性髓细胞白血病患者接受了放化疗和骨髓移植治疗。4例中有3例在移植后3周迅速植入，粒细胞数大于0.10 × 109/L。一名患者在移植后一年继续完全缓解。1例患者出现部分缓解，2例患者在移植后早期死亡。4例患者中有3例骨髓纤维化消失。移植后第22天，残留骨髓纤维化的患者死亡。很明显，骨髓纤维化是可逆的。鉴于缺乏其他有效的治疗方法，对于有合适骨髓供体的急性骨髓炎患者，应考虑将骨髓移植强化治疗作为主要治疗方法。
Four patients with acute myelosclerosis were treated with chemoradiotherapy and bone marrow transplantation. Three of the four had prompt engraftment with greater than 0.10 × 109 granulocytes/liter three weeks after transplantation. One patient continues in complete remission one year after transplantation. One patient experienced a partial remission and two patients died early in the post‐transplantation period. Marrow fibrosis disappeared in three of the four patients. The patient with residual marrow fibrosis died 22 days after transplantation. It is apparent that marrow fibrosis is reversible. In view of the absence of other effective therapy, intensive therapy with marrow transplantation should be considered as primary therapy for patients with acute myelosclerosis who have a suitable marrow donor.