COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions.
COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions.
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DOI：
10.1161/atvbaha.120.314515
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Kaufman DA
中科院分区：
文献类型：
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作者：
Brosnahan SB;Jonkman AH;Kugler MC;Munger JS;Kaufman DA
严重急性呼吸系统综合征冠状病毒2型于二零一九年底成为一种严重的人类病原体，导致2019冠状病毒病（COVID-19）。严重COVID-19最常见的临床表现是与急性呼吸窘迫综合征一致的急性呼吸衰竭。气道、肺实质、肺血管和呼吸神经肌肉疾病都是COVID-19的特征。本文综述了严重急性呼吸综合征冠状病毒2型感染对呼吸系统不同部位的影响，了解呼吸系统疾病的潜在生物学的线索，并强调了当前和未来的翻译和临床研究问题。本文提供了一个图形摘要。
The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome. Airway, lung parenchymal, pulmonary vascular, and respiratory neuromuscular disorders all feature in COVID-19. This article reviews what is known about the effects of severe acute respiratory syndrome coronavirus-2 infection on different parts of the respiratory system, clues to understanding the underlying biology of respiratory disease, and highlights current and future translation and clinical research questions. A graphic abstract is available for this article.