EXPRESSION OF MATRIX METALLOPROTEINASE-2 RELATED TO LYMPH-NODE METASTASIS OF ORAL SQUAMOUS-CELL CARCINOMA - A CLINICOPATHOLOGICAL STUDY
EXPRESSION OF MATRIX METALLOPROTEINASE-2 RELATED TO LYMPH-NODE METASTASIS OF ORAL SQUAMOUS-CELL CARCINOMA - A CLINICOPATHOLOGICAL STUDY
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DOI：
10.1093/ajcp/99.1.18
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发表时间：
1993-01-01
影响因子：
3.5
通讯作者：
MORIMATSU, M
中科院分区：
文献类型：
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作者：
KUSUKAWA, J;SASAGURI, Y;MORIMATSU, M
为探讨基质降解酶在口腔鳞癌恶性潜能中的作用，采用免疫组化法检测了46例口腔鳞癌颈部手术患者组织中基质金属蛋白酶-2（MMP-2/72-kD明胶酶/IV型胶原酶）的表达。在26例有淋巴结转移的患者中，20例（76.9%）proMMP-2强表达，而在20例无淋巴结转移的患者中，仅5例（25%）组织中检测到proMMP-2的产生。在组织标本中，proMMP-2以弥漫性浸润模式和癌的前进前沿表达。由于MMP-2可以降解IV型胶原组成的基底膜，这些结果表明，在体内生产的酶的癌症是一个指标的恶性程度，并proMMP-2表达的分析是有用的，以评估在个别口腔鳞状细胞癌的恶性潜力。
To investigate the effect of matrix-degrading enzymes on the malignant potential of oral squamous cell carcinoma, the expression of matrix metalloproteinase-2 (MMP-2/72-kD gelatinase/type IV collagenase) in 46 patients who had neck surgery for oral cancer was studied immunohistochemically. In 20 of 26 patients (76.9%) with lymph node metastases, proMMP-2 was strongly expressed, whereas the production of proMMP-2 in tissue was detected only in 5 of 20 patients (25%) who had no lymph node metastases. In tissue specimens, proMMP-2 was expressed in a diffuse invasive mode and in the advancing front of cancer. Because MMP-2 can degrade type IV collagen composed of basement membrane, these results suggest that the in vivo production of the enzyme by cancer is an indicator of the degree of malignancy, and that the analysis of proMMP-2 expression is useful to evaluate the malignant potential in individual oral squamous cell carcinoma.