Hydrogel-supported optical-microcavity sensors
Hydrogel-supported optical-microcavity sensors
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DOI：
10.1002/adma.200500261
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发表时间：
2005-09-16
影响因子：
29.4
通讯作者：
Pentland, AA
中科院分区：
文献类型：
--
作者：
DeLouise, LA;Fauchet, PM;Pentland, AA
随着基于硅芯片的生物医学诊断（生物传感器）和治疗（药物输送）技术的广度不断扩大，越来越需要改进生物±设备接口，用于体内和离体应用。生物±设备接口设置了各种机械、材料和准备方面的操作限制，包括样品的收集、处理和应用于设备，以及建立设备生物相容性、对生物污垢的耐受性和固定化生物反应器试剂的稳定性的要求。通常，基于硅芯片的器件（5±10 μm厚），包括微流控微机电系统（MEMS）器件，是由刚性大块硅片支撑（~ 0.5±0.6 mm厚）制造并保持连接的。这种结构可能会限制设备的功能，特别是对于微流体多孔结构，其最佳功能可能取决于流过设备的流动方向。改进生物±器件接口可以显著提高基于芯片的器件的性能特征和多功能性，同时实现新的应用。例如，可以通过开发ª智能绷带来推进伤口护理管理，该绷带的概念是将光学装置（2±10 μm厚）嵌入柔性治疗支撑基质（例如，聚合物凝胶）中。这种结构将通过使ª智能绷带ºto改善生物±设备接口
As the breadth of silicon-chip-based biomedical diagnostic (biosensors) and therapeutic (drug-delivery) technologies continues to expand, there exists a growing need to improve the biological±device interface for both in-vivo and ex-vivo applications. The biological±device interface sets operational constraints on the various mechanical, material, and preparatory aspects of how samples are collected, processed, and applied to a device, as well as on establishing requirements for device biocompatibility, tolerance towards biofouling, and the stability of immobilized bioreagents. Typically, siliconchip-based devices (5±10 μm thick), including microfluidic microelectromechanical systems (MEMS) devices, are fabricated from and remain attached to the rigid bulk-silicon wafer support (∼ 0.5±0.6 mm thick). This architecture may limit device function particularly for microfluidic porous structures, for which optimum function may depend on the directionality of flow through the device. Improving the biological±device interface could significantly advance the performance characteristics and versatility of chip-based devices while enabling new applications. For example, wound-care management could be advanced through the development of a ªsmart bandageº, which is conceptualized as an optical device (2±10 μm thick) embedded in a flexible, therapeutic support matrix (eg, polymeric gel). This architecture would improve the biological±device interface by enabling the ªsmart bandageº to